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  Early [18F]florbetaben and [11C]PiB PET images are a surrogate biomarker of neuronal injury in Alzheimer’s disease

Tiepolt, S., Hesse, S., Patt, M., Luthardt, J., Schroeter, M. L., Hoffmann, K.-T., Weise, D., Gertz, H.-J., Sabri, O., & Barthel, H. (2016). Early [18F]florbetaben and [11C]PiB PET images are a surrogate biomarker of neuronal injury in Alzheimer’s disease. European Journal of Nuclear Medicine and Molecular Imaging, 43(9), 1700-1709. doi:10.1007/s00259-016-3353-1.

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資料種別: 学術論文

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 作成者:
Tiepolt, Solveig1, 著者
Hesse, Swen1, 2, 著者
Patt, Marianne1, 著者
Luthardt, Julia1, 著者
Schroeter, Matthias L.3, 4, 著者           
Hoffmann, Karl-Titus5, 著者
Weise, David6, 著者
Gertz, Hermann-Josef7, 著者
Sabri, Osama1, 2, 著者
Barthel, Henryk1, 著者
所属:
1Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
2Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5Department of Neuroradiology, University of Leipzig, Germany, ou_persistent22              
6Department of Neurology, University of Leipzig, Germany, ou_persistent22              
7Department of Psychiatry, University of Leipzig, Germany, ou_persistent22              

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キーワード: Aβ tracers; [11C]PiB PET; [18F]FBB PET; Alzheimer’s disease; Dual time-point
 要旨: Purpose

[18F]FDG is a commonly used neuronal injury biomarker for early and differential diagnosis of dementia. Typically, the blood supply to the brain is closely coupled to glucose consumption. Early uptake of the Aβ tracer [11C]PiB on PET images is mainly determined by cerebral blood flow and shows a high correlation with [18F]FDG uptake. Uptake data for 18F-labelled Aβ PET tracers are, however, scarce. We investigated the value of early PET images using the novel Aβ tracer [18F]FBB in the diagnosis of Alzhimers disease (AD).
Methods

This retrospective analysis included 22 patients with MCI or dementia who underwent dual time-point PET imaging with either [11C]PiB (11 patients) or [18F]FBB (11 patients) in routine clinical practice. Images were acquired 1 – 9 min after administration of both tracers and 40 – 70 min and 90 – 110 min after administration of [11C]PiB and [18F]FBB, respectively. The patients also underwent [18F]FDG brain PET imaging. PET data were analysed visually and semiquantitatively. Associations between early Aβ tracer uptake and dementia as well as brain atrophy were investigated.
Results

Regional visual scores of early Aβ tracer and [18F]FDG PET images were significantly correlated (Spearman’s ρ = 0.780, P < 0.001). Global brain visual analysis revealed identical results between early Aβ tracer and [18F]FDG PET images. In a VOI-based analysis, the early Aβ tracer data correlated significantly with the [18F]FDG data (r = 0.779, P < 0.001), but there were no differences between [18F]FBB and [11C]PiB. Cortical SUVRs in regions typically affected in AD on early Aβ tracer and [18F]FDG PET images were correlated with MMSE scores (ρ = 0.458, P = 0.032, and ρ = 0.456, P = 0.033, respectively). A voxel-wise group-based search for areas with relatively higher tracer uptake on early Aβ tracer PET images compared with [18F]FDG PET images revealed a small cluster in the midbrain/pons; no significant clusters were found for the opposite comparison.
Conclusion

Early [18F]FBB and [11C]PiB PET brain images are similar to [18F]FDG PET images in AD patients, and these tracers could potentially be used as biomarkers in place of [18F]FDG. Thus, Aβ tracer PET imaging has the potential to provide biomarker information on AD pathology and neuronal injury. The potential of this approach for supporting the diagnosis of AD needs to be confirmed in prospective studies in larger cohorts.

資料詳細

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言語: eng - English
 日付: 2015-11-032016-02-212016-03-302016-08
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子(DOI, ISBNなど): DOI: 10.1007/s00259-016-3353-1
PMID: 27026271
その他: Epub 2016
 学位: -

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出版物 1

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出版物名: European Journal of Nuclear Medicine and Molecular Imaging
  その他 : Eur. J. Nucl. Med. Mol. Imaging
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: Heidelberg, Germany : Springer-Verlag
ページ: - 巻号: 43 (9) 通巻号: - 開始・終了ページ: 1700 - 1709 識別子(ISBN, ISSN, DOIなど): ISSN: 1619-7070
CoNE: https://pure.mpg.de/cone/journals/resource/954925519624