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  The central nervous norepinephrine network links a diminished sense of emotional well-being to an increased body weight

Melasch, J., Rullmann, M., Hilbert, A., Luthardt, J., Becker, G. A., Patt, M., et al. (2016). The central nervous norepinephrine network links a diminished sense of emotional well-being to an increased body weight. International Journal of Obesity, 40(5), 779-787. doi:10.1038/ijo.2015.216.

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Melasch, J.1, 2, Author
Rullmann, M.1, 2, Author
Hilbert, A.1, Author
Luthardt, J.2, Author
Becker, G. A.2, Author
Patt, M.2, Author
Villringer, Arno1, 3, 4, Author              
Arélin, Katrin3, 4, Author              
Meyer, P. M.2, Author
Lobsien, D.5, Author
Ding, Y.-S.6, Author
Mueller, Karsten7, Author              
Sabri, O.1, 2, Author
Hesse, S.1, 2, Author
Pleger, Burkhard1, 3, 4, Author              
1Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
2Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
5Department of Radiology, University Hospital Leipzig, Germany, ou_persistent22              
6Department of Radiology, Psychiatry, and Chemistry, New York University School of Medicine, NY, USA, ou_persistent22              
7Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              


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 Abstract: Objectives: The neurobiological mechanisms linking obesity to emotional distress remain largely undiscovered. Methods: In this pilot study, we combined positron emission tomography, using the norepinephrine transporter (NET) tracer [11C]-O-methylreboxetine, with functional connectivity magnetic resonance imaging, the Beck depression inventory (BDI), and the impact of weight on quality of life–Lite questionnaire (IWQOL–Lite), to investigate the role of norepinephrine in the severity of depression (BDI), as well as in the loss of emotional well-being with body weight (IWQOL–Lite). Results: In a small group of lean-to-morbidly obese individuals (n=20), we show that an increased body mass index (BMI) is related to a lowered NET availability within the hypothalamus, known as the brain’s homeostatic control site. The hypothalamus displayed a strengthened connectivity in relation to the individual hypothalamic NET availability to the anterior insula/frontal operculum, as well as the medial orbitofrontal cortex, assumed to host the primary and secondary gustatory cortex, respectively (n=19). The resting-state activity in these two regions was correlated positively to the BMI and IWQOL–Lite scores, but not to the BDI, suggesting that the higher the resting-state activity in these regions, and hence the higher the BMI, the stronger the negative impact of the body weight on the individual’s emotional well-being was. Conclusions: This pilot study suggests that the loss in emotional well-being with weight is embedded within the central norepinephrine network.


Language(s): eng - English
 Dates: 2015-09-252015-07-292015-09-282015-12-012016-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/ijo.2015.216
PMID: 26620766
PMC: PMC4896494
Other: Epub 2015
 Degree: -



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Title: International Journal of Obesity
  Other : Int. J. Obes.
Source Genre: Journal
Publ. Info: Hampshire, UK : Macmillan Press
Pages: - Volume / Issue: 40 (5) Sequence Number: - Start / End Page: 779 - 787 Identifier: ISSN: 0307-0565
CoNE: https://pure.mpg.de/cone/journals/resource/954925515513_1