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  DNA-Responsive Polyisocyanopeptide Hydrogels with Stress-Stiffening Capacity

Deshpande, S. R., Hammink, R., Das, R. K., Nelissen, F. H. T., Blank, K. G., Rowan, A. E., et al. (2016). DNA-Responsive Polyisocyanopeptide Hydrogels with Stress-Stiffening Capacity. Advanced Functional Materials. doi:10.1002/adfm.201602461.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-34E9-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-34EA-8
Genre: Journal Article

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 Creators:
Deshpande, Swapneel R., Author
Hammink, Roel, Author
Das, Rajat K., Author
Nelissen, Frank H. T., Author
Blank, Kerstin G.1, Author              
Rowan, Alan E., Author
Heus, Hans A., Author
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: DNA, hydrogels, rheology, stimuli responsive, stress-stiffening
 Abstract: Biological materials have evolved to combine a number of functionally relevant properties. They are sensitive to chemical and mechanical signals and respond to these signals in a highly specific manner. Many biological hydrogels possess the ability to stress-stiffen, a property that is difficult to mimic in synthetic systems. A novel synthetic hydrogel is described that possesses stress-stiffening behavior in the biologically relevant stress regime and, at the same time, contains DNA cross-links as stimuli-responsive elements. The hydrogel scaffold is composed of oligo(ethylene glycol)-functionalized polyisocyanopeptides (PIC), which show a sol-to-gel transition upon increasing the temperature. It is shown that the mechanical properties of the hybrid hydrogel depend on DNA cross-linker concentration and temperature. At high temperature, a hydrophobically bundled stress-stiffening PIC network forms. By contrast, gel formation is controlled by DNA cross-linking at temperatures below the PIC sol-to-gel transition. The DNA cross-linked hydrogel also exhibits stress-stiffening behavior and its properties are controlled by the DNA cross-linker concentration. The hydrogel properties can further be tuned when using DNA cross-linkers with different melting temperature or when breaking cross-links by strand displacement. This clearly shows the potential of DNA cross-links as stimuli-responsive elements, highlighting the possible applications of this hybrid hydrogel as a new sensor.

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 Dates: 2016-08-18
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/adfm.201602461
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Title: Advanced Functional Materials
  Other : Adv. Funct. Mater.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH Verlag GmbH
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1616-301X