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  Using carbohydrate-based biomaterials as scaffolds to control human stem cell fate

Hu, J., Seeberger, P. H., & Yin, J. (2016). Using carbohydrate-based biomaterials as scaffolds to control human stem cell fate. Organic & Biomolecular Chemistry, 14(37), 8648-8658. doi:10.1039/C6OB01124A.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-32EF-C Version Permalink: http://hdl.handle.net/21.11116/0000-0006-5986-F
Genre: Journal Article

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2331894.pdf (Publisher version), 2MB
 
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 Creators:
Hu, Jing, Author
Seeberger, Peter H.1, Author              
Yin, Jian, Author
Affiliations:
1Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              

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 Abstract: Given the important roles of carbohydrates in numerous signalling pathways, cell-cell interactions and cell-matrix interactions, a variety of scaffolds based on natural polysaccharides and glycoproteins that are mostly found in the native extracellular matrix (ECM) have been established and investigated as stem cell culture systems. Stem cells have been extensively used in cell therapy and tissue engineering, and the ability to create a suitable environment to direct stem cell behavior is critical for such endeavors. It is a great challenge to construct scaffolds that mimic the native "niche" of stem cells. The present review describes the current statuses and applications of several natural polysaccharide and glycoprotein scaffolds for use in tissue engineering. In the future, carbohydrate-based biomaterials may be used to create powerful scaffolds that can regulate the stem cell fate.

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 Dates: 2016-08-172016
 Publication Status: Published in print
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 Identifiers: DOI: 10.1039/C6OB01124A
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Title: Organic & Biomolecular Chemistry
  Other : Organic and Biomolecular Chemistry
  Abbreviation : Org. Biomol. Chem.
Source Genre: Journal
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Publ. Info: Cambridge : Royal Society of Chemistry
Pages: - Volume / Issue: 14 (37) Sequence Number: - Start / End Page: 8648 - 8658 Identifier: ISSN: 1477-0520