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  Support of academic synthetic chemistry using separation technologies from the pharmaceutical industry

Regalado, E. L., Kozlowski, M. C., Curto, J. M., Ritter, T., Campbell, M. G., Mazzotti, A. R., et al. (2014). Support of academic synthetic chemistry using separation technologies from the pharmaceutical industry. Organic & Biomolecular Chemistry, 12(14), 2161-2166. doi:10.1039/c3ob42195c.

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 Creators:
Regalado, Erik L. 1, Author
Kozlowski, Marisa C. 2, Author
Curto, John M. 2, Author
Ritter, Tobias3, 4, Author           
Campbell, Michael G. 3, Author
Mazzotti,, Anthony R.3, Author
Hamper, Bruce C. 5, Author
Spilling,, Christopher D.5, Author
Mannino, Michael P. 5, Author
Wan, Li6, Author
Yu, Jin-Quan6, Author
Liu, Jinchu 1, Author
Welch, Christopher J.1, Author
Affiliations:
1Merck Research Laboratories, Rahway, New Jersey 07065, USA, ou_persistent22              
2Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA, ou_persistent22              
3Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts, USA, ou_persistent22              
4Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, DE, ou_2040308              
5Department of Chemistry and Biochemistry, University of Missouri, St. Louis, One University Boulevard, St. Louis, Missouri 63121, USA, ou_persistent22              
6Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA, ou_persistent22              

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Free keywords: PERFORMANCE LIQUID-CHROMATOGRAPHY; ALLYLIC HYDROXY PHOSPHONATES; DESIGN SPACE; HPLC; ISOMERS; IDENTIFICATION; RESOLUTION; MOLECULES
 Abstract: The use of state-of-the-art separation tools from the pharmaceutical industry for addressing intractable separation problems from academic synthetic chemistry is evaluated, showing fast and useful results for the resolution of complex mixtures, separation of closely related components, visualization of difficult to detect compounds and purification of synthetic intermediates. Some recommendations for potential near term deployment of separation tools within academia and the evolution of next generation separation technologies are discussed.

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Language(s): eng - English
 Dates: 2013-11-062014-02-202014-03-28
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1039/c3ob42195c
 Degree: -

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Title: Organic & Biomolecular Chemistry
  Other : Organic and Biomolecular Chemistry
  Abbreviation : Org. Biomol. Chem.
Source Genre: Journal
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Affiliations:
Publ. Info: Cambridge : Royal Society of Chemistry
Pages: 7 Volume / Issue: 12 (14) Sequence Number: - Start / End Page: 2161 - 2166 Identifier: ISSN: 1477-0520
CoNE: https://pure.mpg.de/cone/journals/resource/954925269322