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  Accurate prediction of conversion to Alzheimer’s disease using imaging, genetic, and neuropsychological biomarkers

Dukart, J., Sambataro, F., & Bertolino, A. (2016). Accurate prediction of conversion to Alzheimer’s disease using imaging, genetic, and neuropsychological biomarkers. Journal of Alzheimer's Disease, 49(4), 1143-1159. doi:10.3233/JAD-150570.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-2F63-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1A71-1
Genre: Journal Article

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 Creators:
Dukart, Jürgen1, 2, Author              
Sambataro, Fabio1, Author
Bertolino, Alessandro1, 3, Author
Affiliations:
1F. Hoffmann-La Roche, Basel, Switzerland, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari, Italy, ou_persistent22              

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Free keywords: Florbetapir; [18F]fluorodeoxyglucose positron emission tomography; Mild cognitive impairment; Structural magnetic resonance imaging
 Abstract: A variety of imaging, neuropsychological, and genetic biomarkers have been suggested as potential biomarkers for the identification of mild cognitive impairment (MCI) in patients who later develop Alzheimer’s disease (AD). Here, we systematically evaluated the most promising combinations of these biomarkers regarding discrimination between stable and converter MCI and reflection of disease staging. Alzheimer’s Disease Neuroimaging Initiative data of AD (n = 144), controls (n = 112), stable (n = 265) and converter (n = 177) MCI, for which apolipoprotein E status, neuropsychological evaluation, and structural, glucose, and amyloid imaging were available, were included in this study. Naïve Bayes classifiers were built on AD and controls data for all possible combinations of these biomarkers, with and without stratification by amyloid status. All classifiers were then applied to the MCI cohorts. We obtained an accuracy of 76% for discrimination between converter and stable MCI with glucose positron emission tomography as a single biomarker. This accuracy increased to about 87% when including further imaging modalities and genetic information. We also identified several biomarker combinations as strong predictors of time to conversion. Use of amyloid validated training data resulted in increased sensitivities and decreased specificities for differentiation between stable and converter MCI when amyloid was included as a biomarker but not for other classifier combinations. Our results indicate that fully independent classifiers built only on AD and controls data and combining imaging, genetic, and/or neuropsychological biomarkers can more reliably discriminate between stable and converter MCI than single modality classifiers. Several biomarker combinations are identified as strongly predictive for the time to conversion to AD.

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Language(s): eng - English
 Dates: 2015-10-022016-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3233/JAD-150570
PMID: 26599054
 Degree: -

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Title: Journal of Alzheimer's Disease
  Abbreviation : J. Alzheimers Dis.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Amsterdam : IOS Press
Pages: - Volume / Issue: 49 (4) Sequence Number: - Start / End Page: 1143 - 1159 Identifier: ISSN: 1387-2877
CoNE: https://pure.mpg.de/cone/journals/resource/1387-2877