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  Ligand Layer Engineering To Control Stability and Interfacial Properties of Nanoparticles

Schulz, F., Dahl, G. T., Besztejan, S., Schroer, M. A., Lehmkühler, F., Grübel, G., et al. (2016). Ligand Layer Engineering To Control Stability and Interfacial Properties of Nanoparticles. Langmuir, 32(31), 7897-7907. doi:10.1021/acs.langmuir.6b01704.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-30C3-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-30C4-B
Genre: Journal Article

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http://dx.doi.org/10.1021/acs.langmuir.6b01704 (Publisher version)
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 Creators:
Schulz, Florian1, 2, Author
Dahl, Gregor T.1, Author
Besztejan, Stephanie2, 3, 4, Author              
Schroer, Martin A.2, 5, Author
Lehmkühler, Felix2, 5, Author
Grübel, Gerhard2, 5, Author
Vossmeyer, Tobias1, Author
Lange, Holger1, 2, Author
Affiliations:
1Institute for Physical Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany, ou_persistent22              
2The Hamburg Centre for Ultrafast Imaging (CUI), Luruper Chaussee 149, 22761 Hamburg, Germany, ou_persistent22              
3Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King Platz 6, 20146 Hamburg, Germany, ou_persistent22              
4International Max Planck Research School for Ultrafast Imaging & Structural Dynamics (IMPRS-UFAST), Max Planck Institute for the Structure and Dynamics of Matter, Max Planck Society, ou_2266714              
5Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607 Hamburg, Germany, ou_persistent22              

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 Abstract: The use of mixed ligand layers including poly(ethylene glycol)-based ligands for the functionalization of nanoparticles is a very popular strategy in the context of nanomedicine. However, it is challenging to control the composition of the ligand layer and maintain high colloidal and chemical stability of the conjugates. A high level of control and stability are crucial for reproducibility, upscaling, and safe application. In this study, gold nanoparticles with well-defined mixed ligand layers of α-methoxypoly(ethylene glycol)-ω-(11-mercaptoundecanoate) (PEGMUA) and 11-mercaptoundecanoic acid (MUA) were synthesized and characterized by ATR-FTIR spectroscopy and gel electrophoresis. The colloidal and chemical stability of the conjugates was tested by dynamic light scattering (DLS), small-angle X-ray scattering (SAXS), and UV/vis spectroscopy based experiments, and their interactions with cells were analyzed by elemental analysis. We demonstrate that the alkylene spacer in PEGMUA is the key feature for the controlled synthesis of mixed layer conjugates with very high colloidal and chemical stability and that a controlled synthesis is not possible using regular PEG ligands without the alkylene spacer. With the results of our stability tests, the molecular structure of the ligands can be clearly linked to the colloidal and chemical stabilization. We expect that the underlying design principle can be generalized to improve the level of control in nanoparticle surface chemistry.

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Language(s): eng - English
 Dates: 2016-07-182016-05-042016-07-262016-08-09
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1021/acs.langmuir.6b01704
 Degree: -

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Title: Langmuir
Source Genre: Journal
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Publ. Info: Columbus, OH : American Chemical Society
Pages: - Volume / Issue: 32 (31) Sequence Number: - Start / End Page: 7897 - 7907 Identifier: ISSN: 0743-7463
CoNE: https://pure.mpg.de/cone/journals/resource/954925541194