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  Source-reconstruction of event-related fields reveals hyperfunction and hypofunction of cortical circuits in antipsychotic-naive, first-episode schizophrenia patients during Mooney face processing

Rivolta, D., Castellanos, N. P., Stawowsky, C., Helbling, S., Wibral, M., Gruetzner, C., et al. (2014). Source-reconstruction of event-related fields reveals hyperfunction and hypofunction of cortical circuits in antipsychotic-naive, first-episode schizophrenia patients during Mooney face processing. The Journal of Neuroscience, 34(17), 5909-5917. doi:10.1523/JNEUROSCI.3752-13.2014.

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 Creators:
Rivolta, Davide1, 2, 3, Author
Castellanos, Natalie P.4, Author
Stawowsky, Cerisa5, Author
Helbling, Saskia6, Author           
Wibral, Michael5, Author
Gruetzner, Christine1, Author
Koethe, Dagmar7, 8, 9, Author
Birkner, Katharina1, 2, Author
Kranaster, Laura7, 8, Author
Enning, Frank8, Author
Singer, Wolf1, 2, 10, Author
Leweke, F. Markus7, 8, Author
Uhlhaas, Peter1, 2, 11, Author
Affiliations:
1Department of Neurophysiology, Max Planck Institute for Brain Research, Frankfurt, Germany, ou_persistent22              
2Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany, ou_persistent22              
3School of Psychology, University of East London, United Kingdom, ou_persistent22              
4Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Technical University of Madrid, Spain, ou_persistent22              
5MEG Unit, Brain Imaging Centre, Goethe University, Frankfurt, Germany, ou_persistent22              
6Institute of Medical Psychology, Goethe University, Frankfurt, Germany, ou_persistent22              
7Department of Psychiatry and Psychotherapy, University Hospital Cologne, Germany, ou_persistent22              
8Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany, ou_persistent22              
9Department of General Psychiatry, Heidelberg University Hospital, Germany, ou_persistent22              
10Frankfurt Institute for Advanced Studies, Goethe University, Frankfurt, Germany, ou_persistent22              
11Institute of Neuroscience and Psychology, University of Glasgow, United Kingdom, ou_persistent22              

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Free keywords: ERFs; Face processing; First-episode psychosis; M170; MEG; Mooney faces
 Abstract: Schizophrenia is characterized by dysfunctions in neural circuits that can be investigated with electrophysiological methods, such as EEG
and MEG. In the present human study, we examined event-related fields (ERFs), in a sample of medication-naive, first-episode schizo-
phrenia (FE-ScZ) patients (n ϭ 14) and healthy control participants (n ϭ 17) during perception of Mooney faces to investigate the
integrity of neuromagnetic responses and their experience-dependent modification. ERF responses were analyzed for M100, M170, and
M250 components at the sensor and source levels. In addition, we analyzed peak latency and adaptation effects due to stimulus repetition.
FE-ScZ patients were characterized by significantly impaired sensory processing, as indicated by a reduced discrimination index (AЈ). At
the sensor level, M100 and M170 responses in FE-ScZ were within the normal range, whereas the M250 response was impaired. However,
source localization revealed widespread elevated activity for M100 and M170 in FE-ScZ and delayed peak latencies for the M100 and M250
responses. In addition, M170 source activity in FE-ScZ was not modulated by stimulus repetitions. The present findings suggest that
neural circuits in FE-ScZ may be characterized by a disturbed balance between excitation and inhibition that could lead to a failure to gate
information flow and abnormal spreading of activity, which is compatible with dysfunctional glutamatergic neurotransmission.

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Language(s): eng - English
 Dates: 2013-09-022014-03-072014-04-23
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1523/JNEUROSCI.3752-13.2014
PMID: 24760850
 Degree: -

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Title: The Journal of Neuroscience
  Abbreviation : J. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, DC : Society of Neuroscience
Pages: - Volume / Issue: 34 (17) Sequence Number: - Start / End Page: 5909 - 5917 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1