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  Ablation of BAF170 in developing and postnatal dentate gyrus affects neural stem cell proliferation, differentiation, and learning.

Tuoc, T., Dere, E., Radyushkin, K., Pham, L., Nguyen, H., Tonchev, A. B., et al. (2017). Ablation of BAF170 in developing and postnatal dentate gyrus affects neural stem cell proliferation, differentiation, and learning. Molecular Neurobiology, 54(6), 4618-4635. doi:10.1007/s12035-016-9948-5.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-41BB-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-2F92-6
Genre: Journal Article

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 Creators:
Tuoc, T.1, Author              
Dere, E., Author
Radyushkin, K., Author
Pham, L., Author
Nguyen, H., Author
Tonchev, A. B.1, Author              
Sun, G., Author
Ronnenberg, A., Author
Shi, Y., Author
Staiger, J. F., Author
Ehrenreich, H., Author
Stoykova, A.1, Author              
Affiliations:
1Research Group of Molecular Developmental Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578587              

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Free keywords: SWI/SNF complex; BAF170; Hippocampus; Adult neuronal stem cells neurogenesis; Astrogenesis; Learning and memory Adult neuronal stem cells neurogenesis; Astrogenesis; BAF170; Hippocampus; Learning and memory; SWI/SNF
 Abstract: The BAF chromatin remodeling complex plays an essential role in brain development. However its function in postnatal neurogenesis in hippocampus is still unknown. Here, we show that in postnatal dentate gyrus (DG), the BAF170 subunit of the complex is expressed in radial glial-like (RGL) progenitors and in cell types involved in subsequent steps of adult neurogenesis including mature astrocytes. Conditional deletion of BAF170 during cortical late neurogenesis as well as during adult brain neurogenesis depletes the pool of RGL cells in DG, and promotes terminal astrocyte differentiation. These derangements are accompanied by distinct behavioral deficits, as reflected by an impaired accuracy of place responding in the Morris water maze test, during both hidden platform as well as reversal learning. Inducible deletion of BAF170 in DG during adult brain neurogenesis resulted in mild spatial learning deficits, having a more pronounced effect on spatial learning during the reversal test. These findings demonstrate involvement of BAF170-dependent chromatin remodeling in hippocampal neurogenesis and cognition and suggest a specific role of adult neurogenesis in DG in adaptive behavior.

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Language(s): eng - English
 Dates: 2016-07-082017-08
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s12035-016-9948-5
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Title: Molecular Neurobiology
Source Genre: Journal
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Pages: - Volume / Issue: 54 (6) Sequence Number: - Start / End Page: 4618 - 4635 Identifier: -