English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Resting-state functional magnetic resonance imaging of the subthalamic microlesion and stimulation effects in Parkinson's disease: Indications of a principal role of the brainstem

Holiga, S., Mueller, K., Möller, H. E., Urgosik, D., Ruzicka, E., Schroeter, M. L., et al. (2015). Resting-state functional magnetic resonance imaging of the subthalamic microlesion and stimulation effects in Parkinson's disease: Indications of a principal role of the brainstem. NeuroImage: Clinical, 9, 264-274. doi:10.1016/j.nicl.2015.08.008.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-41D2-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-605D-9
Genre: Journal Article

Files

show Files
hide Files
:
Holiga_2015.pdf (Publisher version), 2MB
Name:
Holiga_2015.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Holiga, Stefan1, 2, Author              
Mueller, Karsten1, Author              
Möller, Harald E.1, Author              
Urgosik, Dusan3, Author
Ruzicka, Evzen4, Author
Schroeter, Matthias L.2, 5, Author              
Jech, Robert4, Author
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
3Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech Republic, ou_persistent22              
4Department of Neurology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

Content

show
hide
Free keywords: Parkinson's disease; Microlesion effect; Brainstem; Resting-state fMRI; Deep-brain stimulation; Subthalamic nucleus
 Abstract: During implantation of deep-brain stimulation (DBS) electrodes in the target structure, neurosurgeons and neurologists commonly observe a “microlesion effect” (MLE), which occurs well before initiating subthalamic DBS. This phenomenon typically leads to a transitory improvement of motor symptoms of patients suffering from Parkinson's disease (PD). Mechanisms behind MLE remain poorly understood. In this work, we exploited the notion of ranking to assess spontaneous brain activity in PD patients examined by resting-state functional magnetic resonance imaging in response to penetration of DBS electrodes in the subthalamic nucleus. In particular, we employed a hypothesis-free method, eigenvector centrality (EC), to reveal motor-communication-hubs of the highest rank and their reorganization following the surgery; providing a unique opportunity to evaluate the direct impact of disrupting the PD motor circuitry in vivo without prior assumptions. Penetration of electrodes was associated with increased EC of functional connectivity in the brainstem. Changes in connectivity were quantitatively related to motor improvement, which further emphasizes the clinical importance of the functional integrity of the brainstem. Surprisingly, MLE and DBS were associated with anatomically different EC maps despite their similar clinical benefit on motor functions. The DBS solely caused an increase in connectivity of the left premotor region suggesting separate pathophysiological mechanisms of both interventions. While the DBS acts at the cortical level suggesting compensatory activation of less affected motor regions, the MLE affects more fundamental circuitry as the dysfunctional brainstem predominates in the beginning of PD. These findings invigorate the overlooked brainstem perspective in the understanding of PD and support the current trend towards its early diagnosis.

Details

show
hide
Language(s): eng - English
 Dates: 2015-07-312015-02-022015-08-142015-08-21
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.nicl.2015.08.008
PMID: 26509113
PMC: PMC4576412
Other: eCollection 2015
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: NeuroImage: Clinical
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Elsevier
Pages: - Volume / Issue: 9 Sequence Number: - Start / End Page: 264 - 274 Identifier: ISSN: 2213-1582
CoNE: /journals/resource/2213-1582