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  Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection

Hernandez, P. P., Mahlakoiv, T., Yang, I., Schwierzeck, V., Nguyen, N., Guendel, F., et al. (2015). Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection. Nature Immunology, 16, 698-707. doi:DOI: 10.1038/ni.3180.

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Item Permalink: https://hdl.handle.net/someHandle/test/escidoc:902517 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-9995-B
Genre: Journal Article

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 Creators:
Hernandez, Pedro P.1, 2, 3, Author
Mahlakoiv, Tanel4, 5, Author
Yang, Ines6, 7, Author
Schwierzeck, Vera1, 2, Author
Nguyen, Nam2, Author
Guendel, Fabian1, 2, 8, Author
Gronke, Konrad1, 2, 3, 8, Author
Ryffel, Bernhard9, 10, 11, Author
Hölscher, Christoph12, 13, Author
Dumoutier, Laure14, Author
Renauld, Jean-Christophe14, Author
Suerbaum, Sebastian6, 7, Author
Staehli, Peter4, Author
Diefenbach, Andreas1, 2, 8, Author
Affiliations:
1Research Centre Immunology and Institute of Medical Microbiology and Hygiene, University of Mainz Medical Centre, Mainz, Germany, ou_persistent22              
2Department of Medical Microbiology and Hygiene, Institute for Medical Microbiology and Hygiene, Freiburg University Medical Centre, Freiburg, Germany, ou_persistent22              
3Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              
4Department of Medical Microbiology and Hygiene, Institute for Virology, Freiburg University Medical Centre, Freiburg, Germany, ou_persistent22              
5Spemann Graduate School of Biology and Medicine, University of Freiburg, Freiburg, Germany, ou_persistent22              
6Institute of Medical Microbiology and Hospital Epidemiiology, Hannover Medical School, Hannover, Germany, ou_persistent22              
7German Center for Infection Research, Hannover, Germany, ou_persistent22              
8Research Training Group (GRK1104) of Organogenesis , Freiburg, Germany, ou_persistent22              
9INEM-UMR7355, Molecular Immunology, University of Orleans, Orleans, France, ou_persistent22              
10CNRS, Orleans, France, ou_persistent22              
11Institute of Cape Town, Cape Town, South Africa, ou_persistent22              
12Infection Immunology Research, Research Center Borstel, Borstel, Germany, ou_persistent22              
13Cluster of Excellence Inflammation at Interfaces, Borstel-Kiel-Lübeck-Plön, Germany, ou_persistent22              
14Ludwig Institute for Cancer Research, Université Catholique de Louvain, Brussels, Belgium, ou_persistent22              

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 Abstract: The epithelium is the main entry point for many viruses, but the processes that protect barrier surfaces against viral infections are incompletely understood. Here we identified interleukin 22 (IL-22) produced by innate lymphoid cell group 3 (ILC3) as an amplifier of signaling via interferon-λ (IFN-λ), a synergism needed to curtail the replication of rotavirus, the leading cause of childhood gastroenteritis. Cooperation between the receptor for IL-22 and the receptor for IFN-λ, both of which were 'preferentially' expressed by intestinal epithelial cells (IECs), was required for optimal activation of the transcription factor STAT1 and expression of interferon-stimulated genes (ISGs). These data suggested that epithelial cells are protected against viral replication by co-option of two evolutionarily related cytokine networks. These data may inform the design of novel immunotherapy for viral infections that are sensitive to interferons.

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Language(s): eng - English
 Dates: 2015-05-25
 Publication Status: Issued
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: DOI: 10.1038/ni.3180
 Degree: -

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Title: Nature Immunology
  Other : Nat. Immunol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Nature America Inc.
Pages: 10 Volume / Issue: 16 Sequence Number: - Start / End Page: 698 - 707 Identifier: ISSN: 1529-2908
Other: 974392607073
CoNE: https://pure.mpg.de/cone/journals/resource/974392607073