English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Satb2 Regulates the differntiationof Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex

Leone, D. P., Heavner, W. E., Ferenczi, E. A., Dobreva, G., Huguendard, J. R., Grosschedl, R., et al. (2015). Satb2 Regulates the differntiationof Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex. Cerebral Cortex, 25, 3406-3419. doi:doi: 10.1093/cercor/bhu156.

Item is

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Leone, Dino P.1, Author
Heavner, Whitney E.1, Author
Ferenczi, Emily A.1, Author
Dobreva, Gergana2, Author              
Huguendard, John R.1, Author
Grosschedl, Rudolf2, Author              
McConnell, Susan K.1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

Content

show
hide
Free keywords: callosal projection neuron, corticospinal tract, Ctip2, development, Fezf2, pyramidal neuron, specification
 Abstract: The chromatin-remodeling protein Satb2 plays a role in the generation of distinct subtypes of neocortical pyramidal neurons. Previous studies have shown that Satb2 is required for normal development of callosal projection neurons (CPNs), which fail to extend axons callosally in the absence of Satb2 and instead project subcortically. Here we conditionally delete Satb2 from the developing neocortex and find that neurons in the upper layers adopt some electrophysiological properties characteristic of deep layer neurons, but projections from the superficial layers do not contribute to the aberrant subcortical projections seen in Satb2 mutants. Instead, axons from deep layer CPNs descend subcortically in the absence of Satb2. These data demonstrate distinct developmental roles of Satb2 in regulating the fates of upper and deep layer neurons. Unexpectedly, Satb2 mutant brains also display changes in gene expression by subcerebral projection neurons (SCPNs), accompanied by a failure of corticospinal tract (CST) formation. Altering the timing of Satb2 ablation reveals that SCPNs require an early expression of Satb2 for differentiation and extension of the CST, suggesting that early transient expression of Satb2 in these cells plays an essential role in development. Collectively these data show that Satb2 is required by both CPNs and SCPNs for proper differentiation and axon pathfinding.

Details

show
hide
Language(s): eng - English
 Dates: 2015-10
 Publication Status: Published online
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: doi: 10.1093/cercor/bhu156
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cerebral Cortex
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Oxford University Press
Pages: 14 Volume / Issue: 25 Sequence Number: - Start / End Page: 3406 - 3419 Identifier: ISSN: 1047-3211
Other: 954925592440
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440