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  An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis

Meunier, S., Shvedunova, M., Van Nguyen, N., Avila, l., Vernos, I., & Akhtar, A. (2015). An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis. Nature Communications, 6: 7889 (2015). doi:10.1038/ncomms8889.

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https://www.nature.com/articles/ncomms8889 (Publisher version)
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 Creators:
Meunier, Sylvian1, Author
Shvedunova, Maria2, Author
Van Nguyen, N.2, Author              
Avila, leonor1, Author
Vernos, Isabelle1, Author
Akhtar, A.2, Author              
Affiliations:
1External Organizations, ou_persistent22              
2Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243643              

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 Abstract: The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. Moreover, we identify KANSL3 as a microtubule minus-end-binding protein, revealing a new class of mitosis-specific microtubule minus-end regulators. By adopting distinct functions in interphase and mitosis, KANSL proteins provide a link to coordinate the tasks of faithful expression and inheritance of the genome during different phases of the cell cycle.

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Language(s): eng - English
 Dates: 2015-08-05
 Publication Status: Published online
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/ncomms8889
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: 10 Volume / Issue: 6 Sequence Number: 7889 (2015) Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723