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  MOF maintains transcriptional programs regulating cellular stress response

Sheikh, B., Bechtel-Walz, W., Lucci, J., Karpuik, O., Hild, I., Hartleben, B., et al. (2016). MOF maintains transcriptional programs regulating cellular stress response. Oncogene, 35, 2698-2710. doi:doi: 10.1038/onc.2015.335.

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Sheikh, B.N.1, Autor
Bechtel-Walz, W.2, Autor
Lucci, Jacopo3, Autor           
Karpuik, O.1, Autor
Hild, I.2, Autor
Hartleben, B.2, Autor
Vornweg, J.2, Autor
Helmstädter, M.2, Autor
Sahyoun, A.H.1, Autor
Bhardwaj, V.1, Autor
Stehle, Thomas4, Autor           
Diehl, S.1, Autor
Kretz, O.2, 5, Autor
Voss, A.K.6, 7, Autor
Thomas, T.6, 7, Autor
Manke, Thomas8, Autor           
Huber, T.B.2, 9, Autor
Akhtar, Asifa3, Autor           
Affiliations:
1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              
2Renal Division, University Medical Center, Freiburg, Germany, ou_persistent22              
3Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243643              
4Metchnikoff Laboratory, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243654              
5Neuroanatomy, University Freiburg, Freiburg, Germany, ou_persistent22              
6Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia, ou_persistent22              
7Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia, ou_persistent22              
8Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243644              
9BIOSS Centre for Biological Signaling Studies, Albert-Ludwigs-University, Freiburg, Germany, ou_persistent22              

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 Zusammenfassung: MOF (MYST1, KAT8) is the major H4K16 lysine acetyltransferase (KAT) in Drosophila and mammals and is essential for embryonic development. However, little is known regarding the role of MOF in specific cell lineages. Here we analyze the differential role of MOF in proliferating and terminally differentiated tissues at steady state and under stress conditions. In proliferating cells, MOF directly binds and maintains the expression of genes required for cell cycle progression. In contrast, MOF is dispensable for terminally differentiated, postmitotic glomerular podocytes under physiological conditions. However, in response to injury, MOF is absolutely critical for podocyte maintenance in vivo. Consistently, we detect defective nuclear, endoplasmic reticulum and Golgi structures, as well as presence of multivesicular bodies in vivo in podocytes lacking Mof following injury. Undertaking genome-wide expression analysis of podocytes, we uncover several MOF-regulated pathways required for stress response. We find that MOF, along with the members of the non-specific lethal but not the male-specific lethal complex, directly binds to genes encoding the lysosome, endocytosis and vacuole pathways, which are known regulators of podocyte maintenance. Thus, our work identifies MOF as a key regulator of cellular stress response in glomerular podocytes.

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Sprache(n): eng - English
 Datum: 2016-05
 Publikationsstatus: Erschienen
 Seiten: 13
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: doi: 10.1038/onc.2015.335
 Art des Abschluß: -

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Titel: Oncogene
Genre der Quelle: Zeitschrift
 Urheber:
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Ort, Verlag, Ausgabe: Basingstoke, Hampshire, UK : Scientific & Medical Division, Macmillan Press
Seiten: 13 Band / Heft: 35 Artikelnummer: - Start- / Endseite: 2698 - 2710 Identifikator: ISSN: 0950-9232
Anderer: 954925574955
CoNE: https://pure.mpg.de/cone/journals/resource/954925574955