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  Responsiveness of B cell is regulated by hinge region of IgD

Übelhart, R., Hug, E., Bach, M. P., Wossning, T., Dühren-von Minden, M., Horn, A. H., et al. (2015). Responsiveness of B cell is regulated by hinge region of IgD. Nature Immunology, 16, 534-543. doi:doi: 10.1038/ni.3141.

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 Creators:
Übelhart, Rudolf1, Author
Hug, Eva1, Author
Bach, Martina P.1, Author
Wossning, Thomas2, Author
Dühren-von Minden, Marcus1, 3, Author
Horn, Anselm H.C.4, Author
Tsiantoulas, Dimitrios5, Author
Kometani, Kohei6, Author
Kurosaki, Tomohiro7, 8, Author
Binder, Christoph J.5, Author
Sticht, Heinrich4, Author
Nitschke, Lars9, Author
Reth, Michael2, 3, 10, Author           
Jumaa, Hassan1, 2, 3, Author
Affiliations:
1Institute of Immunology, University Hospital Ulm, Ulm, Germany, ou_persistent22              
2BIOSS Center for Biological Signaling Studies, Albert-Ludwigs University of Freiburg, Freiburg, Germany, ou_persistent22              
3Department of Molecular Immunology, Biology III, Faculty of Biology, Albert-Ludwigs University of Freiburg, Freiburg, Germany, ou_persistent22              
4Department of Bioinformatics, Institute for Biochemistry, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany, ou_persistent22              
5Department of Laboratory Medicine, Medical University of Vienna and Center for Molecular Medicine (CeMM), Austrian Academy of Sciences, Vienna, Austria, ou_persistent22              
6Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              
7Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS), Kanagawa, Japan, ou_persistent22              
8Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan, ou_persistent22              
9Chair of Genetics, Department of Biology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany, ou_persistent22              
10Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243645              

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 Abstract: Mature B cells express immunoglobulin M (IgM)- and IgD-isotype B cell antigen receptors, but the importance of IgD for B cell function has been unclear. By using a cellular in vitro system and corresponding mouse models, we found that antigens with low valence activated IgM receptors but failed to trigger IgD signaling, whereas polyvalent antigens activated both receptor types. Investigations of the molecular mechanism showed that deletion of the IgD-specific hinge region rendered IgD responsive to monovalent antigen, whereas transferring the hinge to IgM resulted in responsiveness only to polyvalent antigen. Our data suggest that the increased IgD/IgM ratio on conventional B-2 cells is important for preferential immune responses to antigens in immune complexes, and that the increased IgM expression on B-1 cells is essential for B-1 cell homeostasis and function.

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Language(s): eng - English
 Dates: 2015-05
 Publication Status: Issued
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: doi: 10.1038/ni.3141
 Degree: -

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Title: Nature Immunology
  Other : Nat. Immunol.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: 10 Volume / Issue: 16 Sequence Number: - Start / End Page: 534 - 543 Identifier: ISSN: 1529-2908
Other: 974392607073
CoNE: https://pure.mpg.de/cone/journals/resource/974392607073