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  Plasma membrane reorganization: A glycolipid gateway for microbes

Aigal, S., Claudinon, J., & Römer, W. (2015). Plasma membrane reorganization: A glycolipid gateway for microbes. Biochimica et Biophysica Acta-Molecular Cell Research, 1853, 858-871. doi:doi: 10.1016/j.bbamcr.2014.11.014.

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Datensatz-Permalink: https://hdl.handle.net/someHandle/test/escidoc:904164 Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-99B2-B
Genre: Zeitschriftenartikel

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 Urheber:
Aigal, Sahaja1, 2, 3, Autor
Claudinon, Julie1, 2, Autor
Römer, Winfried1, 2, Autor
Affiliations:
1Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg, Germany, ou_persistent22              
2BIOSS Centre for Biological Signaling Studies, Albert-Ludwigs-University Freiburg, Freiburg, Germany, ou_persistent22              
3Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              

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Schlagwörter: -
 Zusammenfassung: Ligand-receptor interactions, which represent the core for cell signaling and internalization processes are largely affected by the spatial configuration of host cell receptors. There is a growing piece of evidence that receptors are not homogeneously distributed within the plasma membrane, but are rather pre-clustered in nanodomains, or clusters are formed upon ligand binding. Pathogens have evolved many strategies to evade the host immune system and to ensure their survival by hijacking plasma membrane receptors that are most often associated with lipid rafts. In this review, we discuss the early stage molecular and physiological events that occur following ligand binding to host cell glycolipids. The ability of various biological ligands (e.g. toxins, lectins, viruses or bacteria) that bind to glycolipids to induce their own uptake into mammalian cells by creating negative membrane curvature and membrane invaginations is explored. We highlight recent trends in understanding nanoscale plasma membrane (re-)organization and present the benefits of using synthetic membrane systems. This article is part of a Special Issue entitled: Nanoscale membrane organisation and signalling.

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Sprache(n): eng - English
 Datum: 2015-04
 Publikationsstatus: Erschienen
 Seiten: 14
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: doi: 10.1016/j.bbamcr.2014.11.014
 Art des Abschluß: -

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Titel: Biochimica et Biophysica Acta-Molecular Cell Research
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY : Elsevier
Seiten: 14 Band / Heft: 1853 Artikelnummer: - Start- / Endseite: 858 - 871 Identifikator: Anderer: 954926938702
ISSN: 0167-4889
CoNE: https://pure.mpg.de/cone/journals/resource/954926938702_4