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  ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes

Voon, H. P., Hughes, J. R., Rode, C., De La Rosa-Velázquez, I. A., Jenuwein, T., Feil, R., et al. (2015). ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes. Cell Reports, 11, 405-418. doi:doi: 10.1016/j.celrep.2015.03.036.

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Item Permalink: http://hdl.handle.net/someHandle/test/escidoc:904165 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-C2DC-8
Genre: Journal Article

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 Creators:
Voon, Hsiao P.J.1, Author
Hughes, Jim R.1, Author
Rode, Christina1, Author
De La Rosa-Velázquez, Inti A.2, Author
Jenuwein, Thomas2, Author              
Feil, Robert3, Author
Higgs, Douglas R.1, Author
Gibbons, Richard J.1, Author
Affiliations:
1MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              
3Institute of Molecular Genetics of Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS), Montpellier, France, ou_persistent22              

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 Abstract: Histone H3.3 is a replication-independent histone variant, which replaces histones that are turned over throughout the entire cell cycle. H3.3 deposition at euchromatin is dependent on HIRA, whereas ATRX/Daxx deposits H3.3 at pericentric heterochromatin and telomeres. The role of H3.3 at heterochromatic regions is unknown, but mutations in the ATRX/Daxx/H3.3 pathway are linked to aberrant telomere lengthening in certain cancers. In this study, we show that ATRX-dependent deposition of H3.3 is not limited to pericentric heterochromatin and telomeres but also occurs at heterochromatic sites throughout the genome. Notably, ATRX/H3.3 specifically localizes to silenced imprinted alleles in mouse ESCs. ATRX KO cells failed to deposit H3.3 at these sites, leading to loss of the H3K9me3 heterochromatin modification, loss of repression, and aberrant allelic expression. We propose a model whereby ATRX-dependent deposition of H3.3 into heterochromatin is normally required to maintain the memory of silencing at imprinted loci.

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Language(s): eng - English
 Dates: 2015-04-21
 Publication Status: Published in print
 Pages: 14
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 Rev. Type: Peer
 Identifiers: DOI: doi: 10.1016/j.celrep.2015.03.036
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Title: Cell Reports
Source Genre: Journal
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Pages: 14 Volume / Issue: 11 Sequence Number: - Start / End Page: 405 - 418 Identifier: -