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  Receptor Dissociation and B-Cell Activation

Yang, J., & Reth, M. (2016). Receptor Dissociation and B-Cell Activation. Current Topics in Microbiology and Immunology, 393, 27-44. doi:doi: 10.1007/82_2015_482.

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 Creators:
Yang, Jianying1, 2, Author              
Reth, Michael1, 2, Author              
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1BIOSS Centre for Biological signalling Studies, Department of Molecular Immunology, Biology III, University of Freiburg, Freiburg, Germany, ou_persistent22              
2Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243645              

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 Abstract: The B-cell antigen receptor (BCR) is one of the most abundant receptors on the surface of B cells with roughly 100,000-200,000 copies per cell. Signaling through the BCR is crucial for the activation and differentiation of B cells. Unlike other receptors, the BCR can be activated by a large set of structurally different ligands, but the molecular mechanism of BCR activation is still a matter of controversy. Although dominant for a long time, the cross-link model (CLM) of BCR activation is not supported by recent studies of the nanoscale organization of the BCR on the surface of resting B cells. In contrast to the prediction of CLM, the numerous BCR complexes on these cells are not randomly distributed monomers but rather form oligomers which reside within membrane confinements. This finding is more in line with the dissociation activation model (DAM), wherein B-cell activation is accompanied by an opening of the auto-inhibited BCR oligomers instead of a cross-linking of the BCR monomers. In this review, we discuss in detail the new findings and their implications for BCR signaling.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Published in print
 Pages: 18
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: doi: 10.1007/82_2015_482
 Degree: -

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Title: Current Topics in Microbiology and Immunology
  Other : Curr. Top. Microbiol. Immunol.
Source Genre: Journal
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Publ. Info: Berlin : Springer-Verlag
Pages: 18 Volume / Issue: 393 Sequence Number: - Start / End Page: 27 - 44 Identifier: Other: 954927662083
ISSN: 0070-217X
CoNE: https://pure.mpg.de/cone/journals/resource/954927662083