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  Catalytic reversible alkene-nitrile interconversion through controllable transfer hydrocyanation

Fang, X., Peng, Y., & Morandi, B. (2016). Catalytic reversible alkene-nitrile interconversion through controllable transfer hydrocyanation. Science, 351(6275), 832-836. doi:10.1126/science.aae0427.

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 Urheber:
Fang, Xianjie1, Autor           
Peng, Yuxing1, Autor           
Morandi, Bill1, Autor           
Affiliations:
1Research Group Morandi, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_persistent22              

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 Zusammenfassung: Nitriles and alkenes are important synthetic intermediates with complementary reactivity that play a central role in the preparation of materials, pharmaceuticals, cosmetics, and agrochemicals. Here, we report a nickel-catalyzed transfer hydrocyanation reaction between a wide range (60 examples) of alkyl nitriles and alkenes. This strategy not only overcomes the toxicity challenge posed by the use of HCN in traditional approaches, but also encompasses distinct chemical advances, including retro-hydrocyanation and anti-Markovnikov regioselectivity. In a broader context, this work highlights an approach to the reversible hydrofunctionalization of alkenes through thermodynamically controlled transfer reactions to circumvent the use of volatile and hazardous reagents in the laboratory.

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Sprache(n): eng - English
 Datum: 2016-02-19
 Publikationsstatus: Erschienen
 Seiten: 5
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1126/science.aae0427
 Art des Abschluß: -

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Titel: Science
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Washington, D.C. : American Association for the Advancement of Science
Seiten: 5 Band / Heft: 351 (6275) Artikelnummer: - Start- / Endseite: 832 - 836 Identifikator: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1