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  Four functionally distinct regions in the left supramarginal gyrus support word processing

Oberhuber, M., Hope, T. M., Seghier, M. L., Parker Jones, O., Prejawa, S., Green, D. W., et al. (2016). Four functionally distinct regions in the left supramarginal gyrus support word processing. Cerebral Cortex, 26(11), 4212-4226. doi:10.1093/cercor/bhw251.

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 Creators:
Oberhuber, Marion1, Author
Hope, Thomas M.1, Author
Seghier, Mohamed L.1, 2, Author
Parker Jones, Oiwi1, 3, 4, Author
Prejawa, Suse1, 5, 6, Author           
Green, David W.7, Author
Price, Cathy J.1, Author
Affiliations:
1Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
2Cognitive Neuroimaging Unit, Emirates College for Advanced Education, Abu Dhabi, United Arab Emirates, ou_persistent22              
3FMRIB Centre, University of Oxford, United Kingdom, ou_persistent22              
4Wolfson College, University of Oxford, United Kingdom, ou_persistent22              
5Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
6Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
7Department of Experimental Psychology, Faculty of Brain Sciences, University College London, United Kingdom, ou_persistent22              

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Free keywords: Functional MRI; Language; Parietal lobe; Phonological processing; Speech production
 Abstract: We used fMRI in 85 healthy participants to investigate whether different parts of the left supramarginal gyrus (SMG) are involved in processing phonological inputs and outputs. The experiment involved 2 tasks (speech production (SP) and one-back (OB) matching) on 8 different types of stimuli that systematically varied the demands on sensory processing (visual vs. auditory), sublexical phonological input (words and pseudowords vs. nonverbal stimuli), and semantic content (words and objects vs. pseudowords and meaningless baseline stimuli). In ventral SMG, we found an anterior subregion associated with articulatory sequencing (for SP > OB matching) and a posterior subregion associated with auditory short-term memory (for all auditory > visual stimuli and written words and pseudowords > objects). In dorsal SMG, a posterior subregion was most highly activated by words, indicating a role in the integration of sublexical and lexical cues. In anterior dorsal SMG, activation was higher for both pseudoword reading and object naming compared with word reading, which is more consistent with executive demands than phonological processing. The dissociation of these four “functionally-distinct” regions, all within left SMG, has implications for differentiating between different types of phonological processing, understanding the functional anatomy of language and predicting the effect of brain damage.

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Language(s): eng - English
 Dates: 2016-09-062016-11
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/cercor/bhw251
PMID: 27600852
PMC: PMC5066832
Other: Epub ahead of print
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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 26 (11) Sequence Number: - Start / End Page: 4212 - 4226 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440