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  Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins

Schweins, T., Geyer, M., Scheffzek, K., Warshel, A., Kalbitzer, H. R., & Wittinghofer, A. (1995). Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins. Nature Structural and Molecular Biology, 2(1), 36-44. doi:10.1038/nsb0195-36.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-4FBE-2 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-4FBF-F
Genre: Journal Article
Alternative Title : Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins

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NatStructBiol_2_1995_36.pdf (Any fulltext), 819KB
 
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http://www.nature.com/nsmb/journal/v2/n1/pdf/nsb0195-36.pdf (Any fulltext)
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https://dx.doi.org/10.1038/nsb0195-36 (Any fulltext)
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 Creators:
Schweins, Thomas, Author
Geyer, Matthias1, Author           
Scheffzek, Klaus1, Author           
Warshel, Arieh, Author
Kalbitzer, Hans Robert1, Author           
Wittinghofer, Alfred1, Author           
Affiliations:
1Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              

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 Abstract: Despite many advances in understanding the structure and function of GTP-binding proteins the mechanism by which these molecules switch from the GTP-bound on-state to the GDP-bound off-state is still poorly understood. Theoretical studies suggest that the activation of the nucleophilic water which hydrolyzes GTP needs a general base. Such a base could not be located in any of the many GTP-binding proteins. Here we present a unique type of linear free energy relationships that not only supports a mechanism for p21ras in which the substrate GTP itself acts as the catalytic base driving the GTPase reaction but can also help to explain why certain mutants of p21ras are oncogenic and others are not.

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Language(s): eng - English
 Dates: 1994-08-301994-12-121995-01-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665406
DOI: 10.1038/nsb0195-36
URI: http://www.ncbi.nlm.nih.gov/pubmed/7719852
URI: http://www.nature.com/nsmb/journal/v2/n1/abs/nsb0195-36.html
Other: 6610
 Degree: -

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Title: Nature Structural and Molecular Biology
  Other : Nature Struct Biol
Source Genre: Journal
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Publ. Info: New York, NY : Nature Pub. Group
Pages: - Volume / Issue: 2 (1) Sequence Number: - Start / End Page: 36 - 44 Identifier: ISSN: 1545-9993
CoNE: https://pure.mpg.de/cone/journals/resource/954925603763