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  Clusters of synaptic inputs on dendrites of layer 5 pyramidal cells in mouse visual cortex

Gökce, O., Bonhoeffer, T., & Scheuss, V. (2016). Clusters of synaptic inputs on dendrites of layer 5 pyramidal cells in mouse visual cortex. eLife, 5: e09222. doi:10.7554/eLife.09222.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-5367-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-538E-4
Genre: Journal Article

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 Creators:
Gökce, Onur1, Author              
Bonhoeffer, Tobias1, Author              
Scheuss, Volker1, Author              
Affiliations:
1Department: Synapses-Circuits-Plasticity / Bonhoeffer, MPI of Neurobiology, Max Planck Society, ou_1113545              

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Free keywords: NEURONS IN-VIVO; CORTICAL-NEURONS; RAT NEOCORTEX; PLASTICITY; NETWORK; SPINES; CONNECTIVITY; INTEGRATION; PHYSIOLOGY; OSCILLATIONSLife Sciences & Biomedicine - Other Topics;
 Abstract: The spatial organization of synaptic inputs on the dendritic tree of cortical neurons plays a major role for dendritic integration and neural computations, yet, remarkably little is known about it. We mapped the spatial organization of glutamatergic synapses between layer 5 pyramidal cells by combining optogenetics and 2-photon calcium imaging in mouse neocortical slices. To mathematically characterize the organization of inputs we developed an approach based on combinatorial analysis of the likelihoods of specific synapse arrangements. We found that the synapses of intralaminar inputs form clusters on the basal dendrites of layer 5 pyramidal cells. These clusters contain 4 to 14 synapses within <= 30 mu m of dendrite. According to the spatiotemporal characteristics of synaptic summation, these numbers suggest that there will be non-linear dendritic integration of synaptic inputs during synchronous activation.

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Language(s): eng - English
 Dates: 2015-06-042016-06-072016-07-19
 Publication Status: Published online
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: ISI: 000380862200001
DOI: 10.7554/eLife.09222
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Project name : Sonderforschungsbereich 870 Bildung und Funktion neuronaler Schaltkreise
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Funding program : SFB 870
Funding organization : Deutsche Forschungsgemeinschaft

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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 5 Sequence Number: e09222 Start / End Page: - Identifier: Other: 2050-084X
CoNE: /journals/resource/2050-084X