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  Fast Application of agonists to isolated membrane patches

Jonas, P. (1995). Fast Application of agonists to isolated membrane patches. In B. Sakmann, & E. Neher (Eds.), Single Channel Recording (pp. 231-243). New York: Springer.

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Alternative Title : Fast Application of agonists to isolated membrane patches

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Sakmann_SingleChannelRec_1995_231.pdf (Any fulltext), 2MB
 
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 Creators:
Jonas, Peter1, Author           
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: At a synapse, the transmitter is stored in synaptic vesicles and is released into the synaptic cleft almost instantaneously upon fusion of these vesicles with the presynaptic membrane. Subsequently, the transmitter diffuses to ligand-gated ion channels in the postsynaptic density, binds to them, and thereby causes channel activation. Unfortunately, we have estimates neither of the exact amount of transmitter in the synaptic vesicle nor of the concentration in the synaptic cleft reaching the postsynaptic receptors, and in some cases even the identity of the transmitter is unknown. These questions may be addressed by modeling of release and diffusion. Such a theoretical approach, however, is based on several assumptions, some of which lack experimental evidence.

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Language(s): eng - English
 Dates: 1995
 Publication Status: Published in print
 Pages: 13
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 Table of Contents: -
 Rev. Type: Peer
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Title: Single Channel Recording
Source Genre: Book
 Creator(s):
Sakmann, B.1, Editor           
Neher, E., Editor
Affiliations:
1 Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701            
Publ. Info: New York : Springer
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 231 - 243 Identifier: ISBN: 978-1-4419-1230-5