English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The nanostructure of murine alveolar bone and its changes due to type 2 diabetes

Pabisch, S., Akabane, C., Wagermaier, W., Roschger, A., Ogura, T., Hyodo, R., et al. (2016). The nanostructure of murine alveolar bone and its changes due to type 2 diabetes. Journal of Structural Biology, 196(2), 223-231. doi:10.1016/j.jsb.2016.09.007.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-600E-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-F733-D
Genre: Journal Article

Files

show Files
hide Files
:
2346253.pdf (Publisher version), 3MB
 
File Permalink:
-
Name:
2346253.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute of Colloids and Interfaces, MTKG; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
Manuskript.pdf (Any fulltext), 1023KB
 
File Permalink:
-
Name:
Manuskript.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute of Colloids and Interfaces, MTKG; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Pabisch, Silvia1, Author              
Akabane, Chika1, Author
Wagermaier, Wolfgang2, Author              
Roschger, Andreas2, Author              
Ogura, Taku, Author
Hyodo, Ryo, Author
Kataoka, Shinsuke, Author
Tobori, Norio, Author
Okano, Tomomichi, Author
Murakami, Shinya, Author
Fratzl, Peter3, Author              
Weinkamer, Richard1, Author              
Affiliations:
1Richard Weinkamer, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863295              
2Wolfgang Wagermaier, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863296              
3Peter Fratzl, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863294              

Content

show
hide
Free keywords: Alveolar bone; Diabetes; X-ray scattering; Synchrotron radiation; Mouse model; Biomineralization; Mechanobiology
 Abstract: Alveolar bone - the bony ridge containing the tooth sockets – stands out by its remodeling activity where bone is being formed and resorbed at a much higher rate that in any other bony tissue. Teeth that are anchored in the jaw through the periodontal ligament exert very large localized loads during mastication that could lead to a unique adaptation of the collagen/mineral structure in the bone. Our aim was to characterize the nanostructure of alveolar bone and to determine the influence of diabetes on structural characteristics of the mineralized matrix. Using small- and wide-angle X-ray scattering (SAXS/WAXS), we studied a spontaneous diabetic mouse model (KK+) and its corresponding healthy controls (KK-) (n=6) to determine the size and mutual alignment of the mineral nanoparticles embedded in the collagen matrix. On cross-sections (buccal-lingual) of the first molar multiple line scans with a spatial resolution of 30 μm were performed on each sample, from the lingual to the buccal side of the mandible. Mineral particle thickness and length are decreasing towards the tooth in both buccal and lingual sides of alveolar bone. While mineral particles are well aligned with the long axis of the tooth on the buccal side, they are in a quarter of the measurements oriented along two preferred directions on the lingual side. These nanostructural differences can be interpreted as the result of an asymmetric loading during mastication, leading to a tilting of the tooth in its socket. In diabetic mice particle thicknesses are smaller compared to control animals.

Details

show
hide
Language(s):
 Dates: 2016-09-132016
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.jsb.2016.09.007
BibTex Citekey: Pabisch2016
PMID: 0501
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Structural Biology
  Abbreviation : J. Struct. Biol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 196 (2) Sequence Number: - Start / End Page: 223 - 231 Identifier: ISSN: 1047-8477