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  Structure modeling of the acetylcholine receptor channel and related ligand gated channels

von Kitzing, E. (1995). Structure modeling of the acetylcholine receptor channel and related ligand gated channels. In A. Pullmann, & J. Jortner (Eds.), Modelling of Biomolecular Structures and Mechanisms: Proceedings of the Twenty-Seventh Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, May 23–26, 1994 (pp. 39-57). Dordrecht: Springer Netherlands.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-5E3F-9 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-5E40-3
Genre: Conference Paper

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Pullmann_ModBiomolStructMechanisms_1995_39.pdf (Any fulltext), 2MB
 
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 Creators:
von Kitzing, Eberhard1, Author           
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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Free keywords: Acetylcholine receptor channel; model building; energy profile; ion conduction mechanism; constant field approximation; channel pore; multi ion channel: coupled motion
 Abstract: In this model-building study a model for the pore of the acetylcholine receptor channel is proposed. The pore is formed by five α-helices of the M2 segment where three rings of hydrophilic side chains point into the channel lumen. This model is in agreement with most experimental data like photolabeling, drug affinity studies, single channel conductivity measurements and cryo electron microscopy known about this channel. This study predicts a strong coupling of the motion of the ions in the channel to that of the charged and highly hydrophilic amino acid side chains at the channel wall. Due to the negative net-charge in the pore more than a single cation may occupy the pore region. The resulting strong local electric fields make the commonly used constant field approximation obsolete for this type of ion channel.

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Language(s): eng - English
 Dates: 1995
 Publication Status: Issued
 Pages: 19
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: -
 Degree: -

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Title: Twenty-Seventh Jerusalem Symposium on Quantum Chemistry and Biochemistry
Place of Event: Jerusalem
Start-/End Date: 1994-05-23 - 1994-05-26

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Title: Modelling of Biomolecular Structures and Mechanisms: Proceedings of the Twenty-Seventh Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, May 23–26, 1994
Source Genre: Book
 Creator(s):
Pullmann, A., Editor
Jortner, Joshua, Editor
Affiliations:
-
Publ. Info: Dordrecht : Springer Netherlands
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 39 - 57 Identifier: ISBN: 9401104972
ISBN: 9789401104975

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Title: Jerusalem Symposia
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Pages: 479 Volume / Issue: 27 Sequence Number: - Start / End Page: - Identifier: -