English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Dietary patterns, obesity and microstructure of the hippocampus in healthy elderly people

Zhang, R., Huhn, S., Kharabian, S., Beyer, F., Lampe, L., Villringer, A., et al. (2015). Dietary patterns, obesity and microstructure of the hippocampus in healthy elderly people. Talk presented at 12th European Nutrition Conference (FENS). Berlin, Germany. 2015-10-20 - 2015-10-23.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-5DA6-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-7160-2
Genre: Talk

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Zhang, Rui1, Author              
Huhn, Sebastian1, Author              
Kharabian, Shahrzad1, Author              
Beyer, Frauke1, Author              
Lampe, Leonie1, Author              
Villringer, Arno1, Author              
Witte, Veronica1, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

Content

show
hide
Free keywords: Waist-hip ratio; Mean diffusivity; DTI
 Abstract: Introduction:Dietary habits and obesity have been shown to influence human brain structure and function. It is, however, unclear if diet or obesity, measured using body-mass-index (BMI) and waist- hip ratio (WHR), affects the microstructure of the hippocampus, a key area involved in memory functions. Objectives: This study explored whether dietary patterns are associated with BMI, WHR or hippocampal microstructure, measured by diffusion tensor imaging (DTI) in non-demented elderlies. Method / Design: Dietary patterns were identified using exploratory factor analysis on a food frequency questionnaire in 498 participants aged ≥ 60 years in the ongoing LIFE-study (Leipzig, Germany). Individual hippocampal subfields were segmented on high-resolution 3T-magnetic resonance images in a subgroup (n = 190), using FreeSurfer (www.freesurfer.net). Hippocampal mean diffusivity (MD) of each subfield was extracted on co-registered MD maps derived by DTI, using FSL (www.fmrib.ox.ac.uk/fsl/). Dietary patterns, BMI, WHR and MD were correlated using partial correlations adjusted for important confounders. Results: Factor analysis revealed a ‹red meat and high-sugar› and a ‹fish, fruit and vegetable› pattern. The first pattern correlated to WHR (r=0.30, p<0.01), whereas the second one negatively correlated to WHR (r=-0.37 p<0.01). A higher WHR, but not BMI or dietary patterns, correlated to higher MD, indicative of lower microstructural integrity, on the CA2/3 region of the hippocampus (bilateral, r>0.17, p<0.05). Conclusions: We showed here that an unhealthy diet correlates with central obesity, reflected in a higher WHR, which in turn is associated with lower microstructural integrity within specific areas of the hippocampus, independent of confounders. Therefore, an unhealthy diet might indirectly lead to hippocampal microstructural changes via its negative contribution to central obesity. Upcoming analyses now need to clarify if the microstructural changes in hippocampus translate into changes in memory performance, and if dietary interventions could potentially reverse these effects. This might help to develop novel strategies for maintaining brain health.

Details

show
hide
Language(s):
 Dates: 2015-10
 Publication Status: Not specified
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: -
 Degree: -

Event

show
hide
Title: 12th European Nutrition Conference (FENS)
Place of Event: Berlin, Germany
Start-/End Date: 2015-10-20 - 2015-10-23

Legal Case

show

Project information

show

Source

show