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  Chemical exposure-response relationship between air pollutants and reactive oxygen species in the human respiratory tract

Lakey, P. S. J., Berkemeier, T., Tong, H., Arangio, A., Lucas, K., Pöschl, U., et al. (2016). Chemical exposure-response relationship between air pollutants and reactive oxygen species in the human respiratory tract. Scientific Reports, 6: 32916. doi:10.1038/srep32916.

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 Creators:
Lakey, Pascale S. J.1, Author              
Berkemeier, Thomas1, Author              
Tong, Haijie1, Author              
Arangio, Andrea1, Author              
Lucas, Kurt1, Author              
Pöschl, Ulrich1, Author              
Shiraiwa, Manabu1, Author              
Affiliations:
1Multiphase Chemistry, Max Planck Institute for Chemistry, Max Planck Society, ou_1826290              

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 Abstract: Air pollution can cause oxidative stress and adverse health effects such as asthma and other respiratory diseases, but the underlying chemical processes are not well characterized. Here we present chemical exposure-response relations between ambient concentrations of air pollutants and the production rates and concentrations of reactive oxygen species (ROS) in the epithelial lining fluid (ELF) of the human respiratory tract. In highly polluted environments, fine particulate matter (PM2.5) containing redox-active transition metals, quinones, and secondary organic aerosols can increase ROS concentrations in the ELF to levels characteristic for respiratory diseases. Ambient ozone readily saturates the ELF and can enhance oxidative stress by depleting antioxidants and surfactants. Chemical exposure-response relations provide a quantitative basis for assessing the relative importance of specific air pollutants in different regions of the world, showing that aerosol-induced epithelial ROS levels in polluted megacity air can be several orders of magnitude higher than in pristine rainforest air.

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Language(s): eng - English
 Dates: 2016-09-082016
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/srep32916
 Degree: -

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 6 Sequence Number: 32916 Start / End Page: - Identifier: Other: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322