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  Sensory-to-motor integration during auditory repetition: A combined fMRI and lesion study

Jones Parker, O., Prejawa, S., Hope, T. M. H., Oberhuber, M., Seghier, M. L., Leff, A. P., et al. (2014). Sensory-to-motor integration during auditory repetition: A combined fMRI and lesion study. Frontiers in Human Neuroscience, 8: 24. doi:10.3389/fnhum.2014.00024.

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 Creators:
Jones Parker, Oiwi1, 2, Author
Prejawa, Suse1, Author              
Hope, Thomas M. H.1, Author
Oberhuber, Marion1, Author
Seghier, Mohamed L.1, Author
Leff, Alex P.3, Author
Green, David W.4, Author
Price, Cathy J.1, Author
Affiliations:
1Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
2Wolfson College, University of Oxford, United Kingdom, ou_persistent22              
3Institute of Cognitive Neuroscience, University College London, United Kingdom, ou_persistent22              
4Department of Cognitive, Perceptual and Brain Sciences, Institute of Behavioural Neuroscience, University College London, United Kingdom, ou_persistent22              

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Free keywords: fMRI; Lesions; Language; Speech; Aphasia
 Abstract: The aim of this paper was to investigate the neurological underpinnings of auditory-to-motor translation during auditory repetition of unfamiliar pseudowords. We tested two different hypotheses. First we used functional magnetic resonance imaging in 25 healthy subjects to determine whether a functionally defined area in the left temporo-parietal junction (TPJ), referred to as Sylvian-parietal-temporal region (Spt), reflected the demands on auditory-to-motor integration during the repetition of pseudowords relative to a semantically mediated nonverbal sound-naming task. The experiment also allowed us to test alternative accounts of Spt function, namely that Spt is involved in subvocal articulation or auditory processing that can be driven either bottom-up or top-down. The results did not provide convincing evidence that activation increased in either Spt or any other cortical area when non-semantic auditory inputs were being translated into motor outputs. Instead, the results were most consistent with Spt responding to bottom up or top down auditory processing, independent of the demands on auditory-to-motor integration. Second, we investigated the lesion sites in eight patients who had selective difficulties repeating heard words but with preserved word comprehension, picture naming and verbal fluency (i.e., conduction aphasia). All eight patients had white-matter tract damage in the vicinity of the arcuate fasciculus and only one of the eight patients had additional damage to the Spt region, defined functionally in our fMRI data. Our results are therefore most consistent with the neurological tradition that emphasizes the importance of the arcuate fasciculus in the non-semantic integration of auditory and motor speech processing.

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Language(s): eng - English
 Dates: 2013-07-112014-01-142014-01-31
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fnhum.2014.00024
PMID: 24550807
PMC: PMC3908611
Other: eCollection 2014
 Degree: -

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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 8 Sequence Number: 24 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5161