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  Distinguishing the effect of lesion load from tract disconnection in the arcuate and uncinate fasciculi

Hope, T. M., Seghier, M. L., Prejawa, S., Leff, A. P., & Price, C. J. (2016). Distinguishing the effect of lesion load from tract disconnection in the arcuate and uncinate fasciculi. NeuroImage, 125, 1169-1173. doi:10.1016/j.neuroimage.2015.09.025.

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Hope_Seghier_2016.pdf (Verlagsversion), 522KB
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692449/ (beliebiger Volltext)
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 Urheber:
Hope, Thomas M.H.1, Autor
Seghier, Mohamed L.1, Autor
Prejawa, Suse1, Autor           
Leff, Alex P.2, 3, Autor
Price, Cathy J.1, Autor
Affiliations:
1Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
2Institute of Cognitive Neuroscience, University College London, United Kingdom, ou_persistent22              
3Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              

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Schlagwörter: MRI; Stroke; Language; Outcomes; White matter
 Zusammenfassung: Brain imaging studies of functional outcomes after white matter damage have quantified the severity of white matter damage in different ways. Here we compared how the outcome of such studies depends on two different types of measurements: the proportion of the target tract that has been destroyed (‘lesion load’) and tract disconnection. We demonstrate that conclusions from analyses based on two examples of these measures diverge and that conclusions based solely on lesion load may be misleading.

First, we reproduce a recent lesion-load-only analysis which suggests that damage to the arcuate fasciculus, and not to the uncinate fasciculus, is significantly associated with deficits in fluency and naming skills. Next, we repeat the analysis after replacing the measures of lesion load with measures of tract disconnection for both tracts, and observe significant associations between both tracts and both language skills: i.e. the change increases the apparent relevance of the uncinate fasciculus to fluency and naming skills. Finally we show that, in this dataset, disconnection data explains significant variance in both language skills that is not accounted for by lesion load or volume, but lesion load data explains no unique variance in those skills, once disconnection and lesion volume are taken into account.

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Sprache(n): eng - English
 Datum: 2015-07-082015-09-102015-09-212016-01-15
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.neuroimage.2015.09.025
PMID: 26388553
PMC: PMC4692449
Anderer: Epub 2015
 Art des Abschluß: -

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Titel: NeuroImage
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Orlando, FL : Academic Press
Seiten: - Band / Heft: 125 Artikelnummer: - Start- / Endseite: 1169 - 1173 Identifikator: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166