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  Application of center-out k-space trajectories to three-dimensional imaging of structure and blood transport in the human brain

Shrestha, M. (2016). Application of center-out k-space trajectories to three-dimensional imaging of structure and blood transport in the human brain. PhD Thesis, University of Leipzig, Germany.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-61E6-B Version Permalink: http://hdl.handle.net/21.11116/0000-0004-D01A-4
Genre: Thesis

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 Creators:
Shrestha, Manoj1, Author              
Möller, Harald E.1, Advisor              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

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 Abstract: A novel non-invasive imaging method of unique k-space trajectory named “3D center-out EPI with cylindrical encoding” was developed and implemented for fast imaging of the human brain. The method based on a variant of 3D hybrid EPI combines advantages of the Cartesian and the radial encoding to achieve ultra-short echo time independent of spatial resolution and reasonably short echo train length yielding a quality image of high signal-to-noise ratio. Unlike rectilinear sampling, the method offers not only less motion and flow artifacts but enables also the undersampling capability. As a result, the method improves temporal resolution by shortening the measurement time. Nonetheless, artifacts induced from long-term drifts of the magnetic field as well as geometrical distortions caused by B0 inhomogeneity were removed with the average phase of the k-space center lines and an additional field map scan. Compared to other cylindrical k-space trajectories based on echo-planar imaging, which lead to progressively increasing echo time upon increasing the spatial resolution, the proposed method offers more benefits. As a significant application, imaging readout of the novel technique was applied to true 3D cine imaging which was later used in the combination of pseudo-continuous arterial spin labeling module in order to track a short arterial spin labeling (ASL) bolus of well-defined length along the fast passage through the large vessel compartment of the brain. Parametric maps of ASL signal change, estimated time-to-peak and ASL bolus width were extracted in order to characterize the macrovascular compartments of the brain-feeding arteries. Consequently, bolus dispersion within a single arterial branch was also assessed.

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Language(s): eng - English
 Dates: 2016-09-052016-09-262016
 Publication Status: Published in print
 Pages: -
 Publishing info: University of Leipzig, Germany
 Table of Contents: -
 Rev. Method: -
 Identifiers: -
 Degree: PhD

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