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  Structural and functional connectivity in healthy aging: Associations for cognition and motor behavior

Hirsiger, S., Koppelmans, V., Merillat, S., Liem, F., Erdeniz, B., Seidler, R. D., et al. (2016). Structural and functional connectivity in healthy aging: Associations for cognition and motor behavior. Human Brain Mapping, 37(3), 855-867. doi:10.1002/hbm.23067.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-7832-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-19EA-A
Genre: Journal Article

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 Creators:
Hirsiger, Sarah1, 2, Author
Koppelmans, Vincent3, Author
Merillat, Susan1, 2, Author
Liem, Franz2, 4, Author              
Erdeniz, Burak3, Author
Seidler, Rachael D.3, 5, 6, 7, Author
Jancke, Lutz1, 2, 4, 8, Author
Affiliations:
1International Normal Aging and Plasticity Imaging Center, University of Zurich, Switzerland, ou_persistent22              
2University Research Priority Program “Dynamics of Healthy Aging”, University of Zurich, Switzerland, ou_persistent22              
3School of Kinesiology, University of Michigan, Ann Arbor, MI, USA, ou_persistent22              
4Division of Neuropsychology, Department of Psychology, University of Zurich, Switzerland, ou_persistent22              
5Department of Psychology, University of Michigan, Ann Arbor, MI, USA, ou_persistent22              
6Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA, ou_persistent22              
7Institute of Gerontology, University of Michigan, Ann Arbor, MI, USA, ou_persistent22              
8Department of Special Education, King Abdulaziz University, Jeddah, Saudi Arabia, ou_persistent22              

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Free keywords: Cingulum; Cognitive aging; Functional connectivity; Multimodal imaging; Tractography
 Abstract: Age-related behavioral declines may be the result of deterioration of white matter tracts, affecting brain structural (SC) and functional connectivity (FC) during resting state. To date, it is not clear if the combination of SC and FC data could better predict cognitive/motor performance than each measure separately. We probed these relationships in the cingulum bundle, a major white matter pathway of the default mode network. We aimed to attain deeper knowledge about: (a) the relationship between age and the cingulum's SC and FC strength, (b) the association between SC and FC, and particularly (c) how the cingulum's SC and FC are related to cognitive/motor performance separately and combined. We examined these associations in a healthy and well-educated sample of 165 older participants (aged 64-85). SC and FC were acquired using probabilistic tractography to derive measures to capture white matter integrity within the cingulum bundle (fractional anisotropy, mean, axial and radial diffusivity) and a seed-based resting-state functional MRI correlation approach, respectively. Participants performed cognitive tests measuring processing speed, memory and executive functions, and motor tests measuring motor speed and grip force. Our data revealed that only SC but not resting state FC was significantly associated with age. Further, the cingulum's SC and FC showed no relation. Different relationships between cognitive/motor performance and SC/FC separately were found, but no additive effect of the combined analysis of cingulum's SC and FC for predicting cognitive/motor performance was apparent.

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Language(s): eng - English
 Dates: 2015-10-212014-12-042015-11-162016-02-092016-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: BibTex Citekey: pmid26663386
DOI: 10.1002/hbm.23067
PMID: 26663386
Other: Epub 2015
 Degree: -

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 37 (3) Sequence Number: - Start / End Page: 855 - 867 Identifier: ISSN: 1065-9471
CoNE: /journals/resource/954925601686