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  Brain size, sex, and the aging brain

Jancke, L., Merillat, S., Liem, F., & Hanggi, J. (2015). Brain size, sex, and the aging brain. Human Brain Mapping, 36(1), 150-169. doi:10.1002/hbm.22619.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-77F4-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-791F-4
Genre: Journal Article

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 Creators:
Jancke, Lutz1, 2, 3, 4, 5, Author
Merillat, Susan3, 4, Author
Liem, Franz1, Author              
Hanggi, Jürgen1, Author
Affiliations:
1Division of Neuropsychology, Department of Psychology, University of Zurich, Switzerland, ou_persistent22              
2Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland, ou_persistent22              
3International Normal Aging and Plasticity Imaging Center, University of Zurich, Switzerland, ou_persistent22              
4University Research Priority Program “Dynamics of Healthy Aging”, University of Zurich, Switzerland, ou_persistent22              
5Department of Special Education, King Abdulaziz University, Jeddah, Saudi Arabia, ou_persistent22              

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Free keywords: Brain size; Sex differences; Morphometry; Magnetic resonance imaging; Neuroanatomy
 Abstract: This study was conducted to examine the statistical influence of brain size on cortical, subcortical, and cerebellar compartmental volumes. This brain size influence was especially studied to delineate interactions with Sex and Age. Here, we studied 856 healthy subjects of which 533 are classified as young and 323 as old. Using an automated segmentation procedure cortical (gray and white matter [GM and WM] including the corpus callosum), cerebellar (GM and WM), and subcortical (thalamus, putamen, pallidum, caudatus, hippocampus, amygdala, and accumbens) volumes were measured and subjected to statistical analyses. These analyses revealed that brain size and age exert substantial statistical influences on nearly all compartmental volumes. Analyzing the raw compartmental volumes replicated the frequently reported Sex differences in compartmental volumes with men showing larger volumes. However, when statistically controlling for brain size Sex differences and Sex × Age interactions practically disappear. Thus, brain size is more important than Sex in explaining interindividual differences in compartmental volumes. The influence of brain size is discussed in the context of an allometric scaling of the compartmental volumes.

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Language(s): eng - English
 Dates: 2014-07-172014-03-202014-08-182014-12-112015-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: BibTex Citekey: pmid25161056
DOI: 10.1002/hbm.22619
PMID: 25161056
Other: Epub 2014
 Degree: -

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 36 (1) Sequence Number: - Start / End Page: 150 - 169 Identifier: ISSN: 1065-9471
CoNE: /journals/resource/954925601686