English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity

Oest, A., Lempradl, A., Casas, E., Weigert, M., Tiko, T., Deniz, M., et al. (2014). Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity. Cell, 159, 1352-1364.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-883C-F Version Permalink: https://hdl.handle.net/21.11116/0000-0006-051B-7
Genre: Journal Article

Files

show Files
hide Files
:
Öst et al..pdf (Publisher version), 4MB
View   Save
File Permalink:
https://hdl.handle.net/21.11116/0000-0006-051C-6
Name:
Öst et al..pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Locator:
https://www.sciencedirect.com/science/article/pii/S0092867414014366?via%3Dihub (Publisher version)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Oest, Anita1, Author           
Lempradl, Adelheid1, Author           
Casas, Eduard2, Author
Weigert, Melanie1, Author           
Tiko, Theodor1, Author           
Deniz, Merdin1, Author
Pantano, Lorena2, Author
Boenisch, Ulrike1, Author
Itskov, Pavel M.2, Author
Stoeckius, Marlon2, Author
Ruf, Marius1, Author           
Rajewsky, Nikolaus2, Author
Reuter, Gunter2, Author
Iovino, Nicola1, Author           
Ribiero, Carlos2, Author
Alenius, Mattias2, Author
Heyne, Steffen1, Author           
Vavouri, Tanya2, Author
Pospisilik, J. Andrew1, Author           
Affiliations:
1Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243644              
2External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: The global rise in obesity has revitalized a search for genetic and epigenetic factors underlying the disease. We present a Drosophila model of paternal-diet-induced intergenerational metabolic reprogramming (IGMR) and identify genes required for its encoding in offspring. Intriguingly, we find that as little as 2 days of dietary intervention in fathers elicits obesity in offspring. Paternal sugar acts as a physiological suppressor of variegation, desilencing chromatin-state-defined domains in both mature sperm and in offspring embryos. We identify requirements for H3K9/K27me3-dependent reprogramming of metabolic genes in two distinct germline and zygotic windows. Critically, we find evidence that a similar system may regulate obesity susceptibility and phenotype variation in mice and humans. The findings provide insight into the mechanisms underlying intergenerational metabolic reprogramming and carry profound implications for our understanding of phenotypic variation and evolution.

Details

show
hide
Language(s): eng - English
 Dates: 2014-12-04
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 701877
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cell
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 159 Sequence Number: - Start / End Page: 1352 - 1364 Identifier: -