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  Suv39h-Dependent H3K9me3 Marks Intact Retrotransposons and Silences LINE Elements in Mouse Embryonic Stem Cells

Bulut-Karslioglu, A., De La Rosa-Valázquez, I. A., Ramirez, F., Barenboim, M., Onishi-Seebacher, M., Arand, J., et al. (2014). Suv39h-Dependent H3K9me3 Marks Intact Retrotransposons and Silences LINE Elements in Mouse Embryonic Stem Cells. Molecular Cell, 55, 277-290. doi:org/10.1016/j.molcel.2014.05.029.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-8849-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-C37F-1
Genre: Journal Article

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Bulut-Karslioglu, Aydan1, Author
De La Rosa-Valázquez, Inti A.1, Author
Ramirez, Fidel1, Author
Barenboim, Maxim, Author
Onishi-Seebacher, Megumi, Author
Arand, Julia, Author
Galán, Carmen1, Author
Winter, Georg E., Author
Engist, Bettina2, Author              
Gerle, Borbala, Author
O'Sullivan, Roderick J., Author
Martens, Joost H. A., Author
Walter, Jörn, Author
Manke, Thomas2, Author              
Lachner, Monika1, Author
Jenuwein, Thomas2, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243644              

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 Abstract: Heterochromatin is required to restrict aberrant expression of retrotransposons, but it remains poorly defined due to the underlying repeat-rich sequences. We dissected Suv39h-dependent histone H3 lysine 9 trimethylation (H3K9me3) by genome-wide ChIP sequencing in mouse embryonic stem cells (ESCs). Refined bioinformatic analyses of repeat subfamilies indicated selective accumulation of Suv39h-dependent H3K9me3 at interspersed repetitive elements that cover ∼5% of the ESC epigenome. The majority of the ∼8,150 intact long interspersed nuclear elements (LINEs) and endogenous retroviruses (ERVs), but only a minor fraction of the >1.8 million degenerate and truncated LINEs/ERVs, are enriched for Suv39h-dependent H3K9me3. Transcriptional repression of intact LINEs and ERVs is differentially regulated by Suv39h and other chromatin modifiers in ESCs but governed by DNA methylation in committed cells. These data provide a function for Suv39h-dependent H3K9me3 chromatin to specifically repress intact LINE elements in the ESC epigenome.

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Language(s): eng - English
 Dates: 2014-07-17
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: org/10.1016/j.molcel.2014.05.029
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Title: Molecular Cell
Source Genre: Journal
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Pages: - Volume / Issue: 55 Sequence Number: - Start / End Page: 277 - 290 Identifier: -