Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
 Lokale TagsFreigabegeschichteDetailsÜbersicht
  Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man

Jais, A., Einwallner, E., Sharif, O., Gossens, K., Tsai-Hsiu Lu, T., Soyal, S. M., et al. (2014). Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man. Cell, 158, 25-40.

Item is

 

einblenden: alle ausblenden: alle

Basisdaten

einblenden: ausblenden:
Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-884B-D Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-884C-B
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Jais, Alexander1, Autor           
Einwallner, Elisa2, Autor
Sharif, Omar, Autor
Gossens, Klaus, Autor
Tsai-Hsiu Lu, Tess1, Autor           
Soyal, Selma M., Autor
Medgyesi, David3, Autor           
Neureiter, Daniel, Autor
Paier-Pourani, Jamile, Autor
Dalgaard, Kevin1, Autor           
Duvigneau, J. Catharina, Autor
Lindroos-Christensen, Josefine, Autor
Zapf, Thea-Cristin, Autor
Amann, Sabine, Autor
Saluzzo, Simona, Autor
Jantscher, Florian, Autor
Stiedl, Patricia, Autor
Todoric, Jelena, Autor
Martins, Rui, Autor
Oberkofler, Hannes, Autor
Müller, Simone, AutorHauser-Kronberger, Cornelia, AutorKenner, Lukas, AutorCasanova, Emilio, AutorSutterlüty-Fall, Hedwig, AutorBilban, Martin, AutorMiller, Karl, AutorKozlov, Andrey V., AutorKrempler, Franz, AutorKnapp, Sylvia, AutorLumeng, Carey N., AutorPatsch, Wolfgang, AutorWagner, Oswald, AutorPospisilik, J. Andrew1, Autor           Esterbauer, Harald, Autor mehr..
Affiliations:
1Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243644              
2Max Planck Society, ou_persistent13              
3Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243645              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Obesity and diabetes affect more than half a billion individuals worldwide. Interestingly, the two conditions do not always coincide and the molecular determinants of "healthy" versus "unhealthy" obesity remain ill-defined. Chronic metabolic inflammation (metaflammation) is believed to be pivotal. Here, we tested a hypothesized anti-inflammatory role for heme oxygenase-1 (HO-1) in the development of metabolic disease. Surprisingly, in matched biopsies from "healthy" versus insulin-resistant obese subjects we find HO-1 to be among the strongest positive predictors of metabolic disease in humans. We find that hepatocyte and macrophage conditional HO-1 deletion in mice evokes resistance to diet-induced insulin resistance and inflammation, dramatically reducing secondary disease such as steatosis and liver toxicity. Intriguingly, cellular assays show that HO-1 defines prestimulation thresholds for inflammatory skewing and NF-κB amplification in macrophages and for insulin signaling in hepatocytes. These findings identify HO-1 inhibition as a potential therapeutic strategy for metabolic disease.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2014-07-03
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 701145
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Cell
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 158 Artikelnummer: - Start- / Endseite: 25 - 40 Identifikator: -