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  Regulation of Heterochromatin Transcription by Snail1/LOXL2 during Epithelial-to-Mesenchymal Transition

Millanes-Romero, A., Herranz, N., Perrera, V., Iturbide, A., Loubat-Casanovas, J., Jesús, G., et al. (2013). Regulation of Heterochromatin Transcription by Snail1/LOXL2 during Epithelial-to-Mesenchymal Transition. Molecular Cell, 52, 746-757.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-88DA-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-88DB-7
Genre: Journal Article

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 Creators:
Millanes-Romero, Alba, Author
Herranz, Nicolás, Author
Perrera, Valentina1, Author              
Iturbide, Ane, Author
Loubat-Casanovas, Jordina, Author
Jesús, Gil, Author
Jenuwein, Thomas1, Author              
García de Herreros, Antonio, Author
Peiró, Sandra, Author
Affiliations:
1Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243644              

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 Abstract: Although heterochromatin is enriched with repressive traits, it is also actively transcribed, giving rise to large amounts of noncoding RNAs. Although these RNAs are responsible for the formation and maintenance of heterochromatin, little is known about how their transcription is regulated. Here, we show that the Snail1 transcription factor represses mouse pericentromeric transcription, acting through the H3K4 deaminase LOXL2. Since Snail1 plays a key role in the epithelial-to-mesenchymal transition (EMT), we analyzed the regulation of heterochromatin transcription in this process. At the onset of EMT, one of the major structural heterochromatin proteins, HP1α, is transiently released from heterochromatin foci in a Snail1/LOXL2-dependent manner, concomitantly with a downregulation of major satellite transcription. Moreover, preventing the downregulation of major satellite transcripts compromised the migratory and invasive behavior of mesenchymal cells. We propose that Snail1 regulates heterochromatin transcription through LOXL2, thus creating the favorable transcriptional state necessary for completing EMT.

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Language(s): eng - English
 Dates: 2013-12-12
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 676363
 Degree: -

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Title: Molecular Cell
Source Genre: Journal
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Pages: - Volume / Issue: 52 Sequence Number: - Start / End Page: 746 - 757 Identifier: -