English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Sensory Map Transfer to the Neocrotex Relies on Pretarget Ordering of Thalamic Axons

Lokmane, L., Proville, R., Narboux-Neme, N., Györy, I., Keita, M., Mailhes, C., et al. (2013). Sensory Map Transfer to the Neocrotex Relies on Pretarget Ordering of Thalamic Axons. Current Biology, 23, 810-816. doi:10.1016/j.cub.2013.03.062.

Item is

Files

show Files

Creators

show
hide
 Creators:
Lokmane, Ludmilla1, Author
Proville, Rémi1, Author
Narboux-Neme, Nicolas1, Author
Györy, Ildiko2, Author              
Keita, Maryama1, Author
Mailhes, Caroline1, Author
Léna, Clément1, Author
Gaspar, Patricia1, Author
Grosschedl, Rudolf2, Author              
Garel, Sonia1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

Content

show
hide
Free keywords: -
 Abstract: Sensory maps, such as the representation of mouse facial whiskers, are conveyed throughout the nervous system by topographic axonal projections that preserve neighboring relationships between adjacent neurons. In particular, the map transfer to the neocortex is ensured by thalamocortical axons (TCAs), whose terminals are topographically organized in response to intrinsic cortical signals. However, TCAs already show a topographic order early in development, as they navigate toward their target. Here, we show that this preordering of TCAs is required for the transfer of the whisker map to the neocortex. Using Ebf1 conditional inactivation that specifically perturbs the development of an intermediate target, the basal ganglia, we scrambled TCA topography en route to the neocortex without affecting the thalamus or neocortex. Notably, embryonic somatosensory TCAs were shifted toward the visual cortex and showed a substantial intermixing along their trajectory. Somatosensory TCAs rewired postnatally to reach the somatosensory cortex but failed to form a topographic anatomical or functional map. Our study reveals that sensory map transfer relies not only on positional information in the projecting and target structures but also on preordering of axons along their trajectory, thereby opening novel perspectives on brain wiring.

Details

show
hide
Language(s): eng - English
 Dates: 2013-05-06
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.cub.2013.03.062
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Current Biology
  Abbreviation : Curr. Biol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London, UK : Cell Press
Pages: - Volume / Issue: 23 Sequence Number: - Start / End Page: 810 - 816 Identifier: ISSN: 0960-9822
CoNE: https://pure.mpg.de/cone/journals/resource/954925579107