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  Molecular Diversity Subdivides the Adult Forebrain Neural Stem Cell Population

Giachino, C., Basak, O., Lugert, S., Knuckles, P., Obernier, K., Fiorelli, R., et al. (2013). Molecular Diversity Subdivides the Adult Forebrain Neural Stem Cell Population. Stem Cells, 32, 70-84.

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 Creators:
Giachino, Claudio1, Author              
Basak, Onur1, Author              
Lugert, Sebastian2, Author              
Knuckles, Philip1, Author              
Obernier, Kirsten, Author
Fiorelli, Roberto, Author
Frank, Stephan, Author
Raineteau, Olivier, Author
Arturo, Alvarez-Buylla, Author
Taylor, Verdon3, Author              
Affiliations:
1Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243651              
2Emeritus Group: Cellular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243649              
3Emeritus Group: Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243656              

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Free keywords: Neurogenesis; Subventricular zone; Neural stem cells; Aging
 Abstract: Neural stem cells (NSCs) in the ventricular domain of the subventricular zone (V-SVZ) of rodents produce neurons throughout life while those in humans become largely inactive or may be lost during infancy. Most adult NSCs are quiescent, express glial markers, and depend on Notch signaling for their self-renewal and the generation of neurons. Using genetic markers and lineage tracing, we identified subpopulations of adult V-SVZ NSCs (type 1, 2, and 3) indicating a striking heterogeneity including activated, brain lipid binding protein (BLBP, FABP7) expressing stem cells. BLBP+ NSCs are mitotically active components of pinwheel structures in the lateral ventricle walls and persistently generate neurons in adulthood. BLBP+ NSCs express epidermal growth factor (EGF) receptor, proliferate in response to EGF, and are a major clonogenic population in the SVZ. We also find BLBP expressed by proliferative ventricular and subventricular progenitors in the fetal and postnatal human brain. Loss of BLBP+ stem/progenitor cells correlates with reduced neurogenesis in aging rodents and postnatal humans. These findings of molecular heterogeneity and proliferative differences subdivide the NSC population and have implications for neurogenesis in the forebrain of mammals during aging.

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Language(s): eng - English
 Dates: 2013
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 674929
 Degree: -

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Title: Stem Cells
Source Genre: Journal
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Pages: - Volume / Issue: 32 Sequence Number: - Start / End Page: 70 - 84 Identifier: -