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  The transcription factor early B-cell factor 1 regulates bone formation in an osteoblast-nonautonomous manner

Zee, T., Boller, S., Györy, I., Tuckermann, J. P., Grosschedl, R., & Karsenty, G. (2013). The transcription factor early B-cell factor 1 regulates bone formation in an osteoblast-nonautonomous manner. FEBS Letters, 587, 711-716. doi:10.1016/j.febslet.2013.01.049.

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 Creators:
Zee, Tiffany1, Author
Boller, Sören2, Author              
Györy, Ildiko2, Author              
Tuckermann, Jan P.1, Author
Grosschedl, Rudolf2, Author              
Karsenty, Gerard1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

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Free keywords: Ebf1; Osteoblast; Bone mass
 Abstract: Early B-cell factor 1 (Ebf1) is a transcription factor whose inactivation in all cells results in high bone mass because of an increase in bone formation. This observation suggests Ebf1 may be an inhibitor of osteoblast differentiation. To test this contention, we analyzed Ebf1 pattern of expression and function in osteoblasts ex vivo and in vivo through osteoblast-specific inactivation in the mouse. We show here that in vivo deletion of Ebf1 in osteoblast progenitors does not affect osteoblast differentiation or bone formation accrual post-natally. These observations indicate that the phenotype described in Ebf1-/- mice is not osteoblast-autonomous.

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Language(s): eng - English
 Dates: 2013-03-18
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.febslet.2013.01.049
 Degree: -

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Title: FEBS Letters
  Other : FEBS Lett.
Source Genre: Journal
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Affiliations:
Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 587 Sequence Number: - Start / End Page: 711 - 716 Identifier: ISSN: 0014-5793
CoNE: https://pure.mpg.de/cone/journals/resource/954925399501