English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 Local TagsRelease HistoryDetailsSummary
  Satb1 and Satb2 Are Dispensable for X Chromosome Inactivation in Mice

Nechanitzky, R., Dávila, A., Savarese, F., Fietze, S., & Grosschedl, R. (2012). Satb1 and Satb2 Are Dispensable for X Chromosome Inactivation in Mice. Developmental Cell, 23, 866-871. doi:10.1016/j.devcel.2012.09.018.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-8CC0-3 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-1D73-6
Genre: Journal Article

Files

show Files
hide Files
:
Nechanitzky 2012_Dev Cell.pdf (Publisher version), 339KB
 
File Permalink:
-
Name:
Nechanitzky 2012_Dev Cell.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute of Immunobiology and Epigenetics, MFIB; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Locator:
https://www.sciencedirect.com/science/article/pii/S1534580712004297?via%3Dihub (Publisher version)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Nechanitzky, Robert1, Author           
Dávila, Amparo1, Author           
Savarese, Fabio1, Author           
Fietze, Stefanie1, Author
Grosschedl, Rudolf1, Author           
Affiliations:
1Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

Content

show
hide
Free keywords: -
 Abstract: Satb1 and Satb2 have been recently described as regulators of embryonic stem (ES) cell pluripotency and as silencing factors in X chromosome inactivation. The influence of the pluripotency machinery on X chromosome inactivation and the lack of an X chromosome inactivation defect in Satb1-/- and Satb2-/- mice raise the question of whether or not Satb proteins are directly and/or redundantly involved in this process. Here, we analyzed X chromosome inactivation in fibroblastic cells that were derived from female Satb1-/-Satb2-/- embryos. By fluorescence in situ hybridization to visualize Xist RNA and by immunohistochemistry to detect H3K27me3 histone modifications, we found that female Satb1-/-Satb2-/- fibroblastic cells contain proper Barr bodies. Moreover, we did not detect an upregulation of X-linked genes, suggesting that Satb proteins are dispensable for X chromosome inactivation in mice.

Details

show
hide
Language(s): eng - English
 Dates: 2012-10-16
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.devcel.2012.09.018
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Developmental Cell
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 23 Sequence Number: - Start / End Page: 866 - 871 Identifier: ISSN: 1534-5807
CoNE: https://pure.mpg.de/cone/journals/resource/111006902714134