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  Drosophila Dosage Compensation Involves Enhanced Pol II Recruitment to Male X-Linked Promoters

Conrad, T., Cavalli, F. M. G., Vaquerizas, J. M., Luscombe, N. M., & Akhtar, A. (2012). Drosophila Dosage Compensation Involves Enhanced Pol II Recruitment to Male X-Linked Promoters. Science, 337, 742-746.

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 Urheber:
Conrad, Thomas1, Autor           
Cavalli, Florence M. G., Autor
Vaquerizas, Juan M., Autor
Luscombe, Nicolas M., Autor
Akhtar, Asifa1, Autor           
Affiliations:
1Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243643              

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 Zusammenfassung: Through hyperacetylation of histone H4 lysine 16 (H4K16), the male-specific lethal (MSL) complex in Drosophila approximately doubles transcription from the single male X chromosome in order to match X-linked expression in females and expression from diploid autosomes. By obtaining accurate measurements of RNA polymerase II (Pol II) occupancies and short promoter-proximal RNA production, we detected a consistent, genome-scale increase in Pol II activity at the promoters of male X-linked genes. Moreover, we found that enhanced Pol II recruitment to male X-linked promoters is largely dependent on the MSL complex. These observations provide insights into how global modulation of chromatin structure by histone acetylation contributes to the precise control of Pol II function.

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Sprache(n): eng - English
 Datum: 2012-08-10
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 629819
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Titel: Science
Genre der Quelle: Zeitschrift
 Urheber:
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 337 Artikelnummer: - Start- / Endseite: 742 - 746 Identifikator: -