English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Drosophila Dosage Compensation Involves Enhanced Pol II Recruitment to Male X-Linked Promoters

Conrad, T., Cavalli, F. M. G., Vaquerizas, J. M., Luscombe, N. M., & Akhtar, A. (2012). Drosophila Dosage Compensation Involves Enhanced Pol II Recruitment to Male X-Linked Promoters. Science, 337, 742-746.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Conrad, Thomas1, Author              
Cavalli, Florence M. G., Author
Vaquerizas, Juan M., Author
Luscombe, Nicolas M., Author
Akhtar, Asifa1, Author              
Affiliations:
1Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243643              

Content

show
hide
Free keywords: -
 Abstract: Through hyperacetylation of histone H4 lysine 16 (H4K16), the male-specific lethal (MSL) complex in Drosophila approximately doubles transcription from the single male X chromosome in order to match X-linked expression in females and expression from diploid autosomes. By obtaining accurate measurements of RNA polymerase II (Pol II) occupancies and short promoter-proximal RNA production, we detected a consistent, genome-scale increase in Pol II activity at the promoters of male X-linked genes. Moreover, we found that enhanced Pol II recruitment to male X-linked promoters is largely dependent on the MSL complex. These observations provide insights into how global modulation of chromatin structure by histone acetylation contributes to the precise control of Pol II function.

Details

show
hide
Language(s): eng - English
 Dates: 2012-08-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 629819
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Science
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 337 Sequence Number: - Start / End Page: 742 - 746 Identifier: -