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  Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription

Conrad, T., & Akhtar, A. (2012). Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription. Nature Reviews Genetics, 13, 123-134. doi:10.1038/nrg3124.

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https://www.nature.com/articles/nrg3124 (Publisher version)
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 Creators:
Conrad, Thomas1, Author              
Akhtar, Asifa1, Author              
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1Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243643              

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 Abstract: Dosage compensation is an epigenetic mechanism that normalizes gene expression from unequal copy numbers of sex chromosomes. Different organisms have evolved alternative molecular solutions to this task. In Drosophila melanogaster, transcription of the single male X chromosome is upregulated by twofold in a process orchestrated by the dosage compensation complex. Despite this conceptual simplicity, dosage compensation involves multiple coordinated steps to recognize and activate the entire X chromosome. We are only beginning to understand the intriguing interplay between multiple levels of local and long-range chromatin regulation required for the fine-tuned transcriptional activation of a heterogeneous gene population. This Review highlights the known facts and open questions of dosage compensation in D. melanogaster.

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Language(s): eng - English
 Dates: 2012-01-18
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/nrg3124
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Title: Nature Reviews Genetics
Source Genre: Journal
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Publ. Info: London, UK : Nature Pub. Group
Pages: - Volume / Issue: 13 Sequence Number: - Start / End Page: 123 - 134 Identifier: ISSN: 1471-0056
CoNE: https://pure.mpg.de/cone/journals/resource/110985821000939