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  Synthetic immune signaling

Schamel, W. W. A., & Reth, M. (2012). Synthetic immune signaling. Current Opinion in Biotechnology, 23, 780-784.

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 Creators:
Schamel, Wolfgang W. A.1, Author              
Reth, Michael1, Author              
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1Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243645              

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 Abstract: A successful immune response against pathogens requires the activation of different cell types of the immune system. These activation processes are difficult to study by classical biochemical and genetic methods alone. In this review we describe how approaches of synthetic biology, such as rebuilding of minimal functional signaling systems and the design of new molecules acting as signaling switches, can be used to get a deeper insight into the signaling mechanism of immune cells. In particular, the interaction of receptors with signal-transducing elements can be studied in detail with these new methods. In addition, sophisticated synthetic immune receptors are being tested in the clinic for gene therapy against certain cancer types.

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Language(s): eng - English
 Dates: 2012
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 634459
 Degree: -

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Title: Current Opinion in Biotechnology
Source Genre: Journal
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Pages: - Volume / Issue: 23 Sequence Number: - Start / End Page: 780 - 784 Identifier: -