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  Histone Demethylase UTX-1 Regulates C.elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway

Jin, C., Li, J., Green, C. D., Yu, X., Tang, X., Han, D., et al. (2011). Histone Demethylase UTX-1 Regulates C.elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway. Cell Metabolism, 14, 161-172.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-8DCC-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-8DCD-5
Genre: Journal Article

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 Creators:
Jin, Chunyu, Author
Li, Jing, Author
Green, Christopher D., Author
Yu, Xiaoming, Author
Tang, Xia, Author
Han, Dali, Author
Xian, Bo, Author
Wang, Dan, Author
Huang, Xinxin, Author
Cao, Xiongwen, Author
Yan, Zheng, Author
Hou, Lei, Author
Liu, Jiancheng, Author
Shukeir, Nicholas1, Author
Khaitovich, Philipp, Author
Chen, Charlie D., Author
Zhang, Hong, Author
Jenuwein, Thomas2, Author              
Han, Jing-dong J., Author
Affiliations:
1Max Planck Society, ou_persistent13              
2Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243644              

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 Abstract: Epigenetic modifications are thought to be important for gene expression changes during development and aging. However, besides the Sir2 histone deacetylase in somatic tissues and H3K4 trimethylation in germlines, there is scant evidence implicating epigenetic regulations in aging. The insulin/IGF-1 signaling (IIS) pathway is a major life span regulatory pathway. Here, we show that progressive increases in gene expression and loss of H3K27me3 on IIS components are due, at least in part, to increased activity of the H3K27 demethylase UTX-1 during aging. RNAi of the utx-1 gene extended the mean life span of C. elegans by ~30%, dependent on DAF-16 activity and not additive in daf-2 mutants. The loss of utx-1 increased H3K27me3 on the Igf1r/daf-2 gene and decreased IIS activity, leading to a more "naive" epigenetic state. Like stem cell reprogramming, our results suggest that reestablishment of epigenetic marks lost during aging might help "reset" the developmental age of animal cells.

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Language(s): eng - English
 Dates: 2011-08-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 577429
 Degree: -

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Title: Cell Metabolism
Source Genre: Journal
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Pages: - Volume / Issue: 14 Sequence Number: - Start / End Page: 161 - 172 Identifier: -