English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 Local TagsRelease HistoryDetailsSummary
  Peripheral Nervous System Progenitors Can Be Reprogrammed to Produce Myelinating Oligodendrocytes and Repair Brain Lesions

Binder, E., Rukavina, M., Hassani, H., Weber, M., Nakatani, H., Reiff, T., et al. (2011). Peripheral Nervous System Progenitors Can Be Reprogrammed to Produce Myelinating Oligodendrocytes and Repair Brain Lesions. The Journal of Neuroscience, 31, 6379-6391.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-8DE2-4 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-8DE3-2
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Binder, Ellen, Author
Rukavina, Marion1, Author           
Hassani, Hessameh, Author
Weber, Marlen, Author
Nakatani, Hiroko, Author
Reiff, Tobias, Author
Parras, Carlos, Author
Taylor, Verdon2, Author           
Rohrer, Hermann, Author
Affiliations:
1Georges Köhler Laboratory, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243653              
2Emeritus Group: Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243656              

Content

show
hide
Free keywords: -
 Abstract: Neural crest stem cells (NCSCs) give rise to the neurons and glia of the peripheral nervous system (PNS). NCSC-like cells can be isolated from multiple peripheral organs and maintained in neurosphere culture. Combining in vitro culture and transplantation, we show that expanded embryonic NCSC-like cells lose PNS traits and are reprogrammed to generate CNS cell types. When transplanted into the embryonic or adult mouse CNS, they differentiate predominantly into cells of the oligodendrocyte lineage without any signs of tumor formation. NCSC-derived oligodendrocytes generate CNS myelin and contribute to the repair of the myelin deficiency in shiverer mice. These results demonstrate a reprogramming of PNS progenitors to CNS fates without genetic modification and imply that PNS cells could be a potential source for cell-based CNS therapy.

Details

show
hide
Language(s): eng - English
 Dates: 2011-04-27
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 576431
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: The Journal of Neuroscience
  Alternative Title : J. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 31 Sequence Number: - Start / End Page: 6379 - 6391 Identifier: -