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  Interactions between subunits of the Mediator complex with gene-specific transcription factors

Borggrefe, T., & Yue, X. (2011). Interactions between subunits of the Mediator complex with gene-specific transcription factors. Seminars in Cell & Developmental Biology, 22, 759-768.

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 Creators:
Borggrefe, Tilman1, Author              
Yue, Xiaojing1, Author              
Affiliations:
1Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

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Free keywords: Mediator complex; Transcriptional regulation; RNA polymerase; Coactivator
 Abstract: The Mediator complex forms the bridge between gene-specific transcription factors and the RNA polymerase II (RNAP II) machinery. Mediator is a large polypetide complex consisting of about thirty polypeptides that are mostly conserved from yeast to human. Mediator coordinates RNAP II recruitment, phosphorylation of the C-terminal domain of RNAP II, enhancer-loop formation and post-initiation events. The focus of the review is to summarize the current knowledge of transcription factor/Mediator interactions in higher eukaryotes and illuminate the physiological and gene-selective roles of Mediator.

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Language(s): eng - English
 Dates: 2011
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 576530
 Degree: -

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Title: Seminars in Cell & Developmental Biology
  Alternative Title : Sem. Cell. Dev. Biol.
Source Genre: Journal
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Pages: - Volume / Issue: 22 Sequence Number: - Start / End Page: 759 - 768 Identifier: -