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  Adenovirus-triggered innate signalling pathways

Fejer, G., Freudenberg, M., Greber, U. F., & Gyory, I. (2011). Adenovirus-triggered innate signalling pathways. European Journal of Microbiology and Immunology, 4, 279-288.

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 Creators:
Fejer, G.1, Author              
Freudenberg, M.1, Author              
Greber, U. F., Author
Gyory, I.2, Author              
Affiliations:
1Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              
2Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

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Free keywords: adenovirus; viral entry; endosomal escape; innate response; Toll-like receptors; type-I interferons; IL-1; IRF7
 Abstract: Adenoviruses are important infectious agents and also emerging vectors in different biomedical applications. These viruses elicit a strong innate and adaptive immune response, which influences both the course of disease and the success of the applied vectors. Several Toll-like Receptor (TLR)-dependent and -independent mechanisms contribute to these responses. Understanding of the involved viral and cellular factors is crucial for the treatment of various adenovirus diseases and the opitmal design of adenovirus vector application. Here we summarize our current understanding of the complex nature of adenovirus-induced innate immune mechanisms.

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Language(s): eng - English
 Dates: 2011
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 576727
 Degree: -

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Title: European Journal of Microbiology and Immunology
  Alternative Title : Eur. J. Microbiol. Immunol.
Source Genre: Journal
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Pages: - Volume / Issue: 4 Sequence Number: - Start / End Page: 279 - 288 Identifier: -