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  Drosophila dosage compensation: males are from Mars, females are from Venus

Georgiev, P., Chlamydas, S., & Akhtar, A. (2011). Drosophila dosage compensation: males are from Mars, females are from Venus. Fly, 5, 147-154. doi:10.4161/fly.5.2.14934.

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 Creators:
Georgiev, Plamen1, Author              
Chlamydas, Sarantis2, Author              
Akhtar, Asifa1, Author              
Affiliations:
1Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243643              
2Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243644              

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Free keywords: dosage compensation; MSL; roX; transcription; acetylation; methylation; X chromosome; nuclear pore complex
 Abstract: Dosage compensation of X-linked genes is a phenomenon of concerted, chromosome-wide regulation of gene expression underpinned by sustained and tightly regulated histone modifications and chromatin remodeling, coupled with constrains of nuclear architecture. This elaborate process allows the accomplishment of regulated expression of genes on the single male X chromosome to levels comparable to those expressed from the two X chromosomes in females. The ribonucleoprotein Male Specific Lethal (MSL) complex is enriched on the male X chromosome and is intricately involved in this process in Drosophila melanogaster. In this review we discuss the recent advances that highlight the complexity lying behind regulation of gene expression by just two-fold.

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Language(s): eng - English
 Dates: 2011-04-01
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.4161/fly.5.2.14934
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Title: Fly
Source Genre: Journal
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Pages: - Volume / Issue: 5 Sequence Number: - Start / End Page: 147 - 154 Identifier: -