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  The dynamics of T cells during persistent Staphylococcus aureus infection: from antigen-reactivity to in vivo anergy

Ziegler, C., Goldmann, O., Hobeika, E., Geffers, R., Peters, G., & Medina, E. (2011). The dynamics of T cells during persistent Staphylococcus aureus infection: from antigen-reactivity to in vivo anergy. EMBO Molecular Medicine, 3, 652-666.

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 Creators:
Ziegler, Christina, Author
Goldmann, Oliver, Author
Hobeika, Elias1, Author           
Geffers, Robert, Author
Peters, Georg, Author
Medina, Eva, Author
Affiliations:
1Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243645              

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Free keywords: immunosuppressive mechanisms; persistent infection; Staphylococcus aureus; T cell anergy; T cell responses
 Abstract: Staphylococcus aureus is an important human pathogen that can cause long-lasting persistent infections. The mechanisms by which persistent infections are maintained involve both bacterial escape strategies and modulation of the host immune response. So far, the investigations in this area have focused on strategies used by S. aureus to persist within the host. Here, we used an experimental mouse model to investigate the host response to persistent S. aureus infection. Our results demonstrated that T cells, which are critical for controlling S. aureus infection, gradually lost their ability to respond to antigenic stimulation and entered a state of anergy with the progression of infection towards persistence. The T cell hyporesponsiveness was reverted by co-stimulation with the phorbol ester PMA, an activator of protein kinase C, suggesting that a failure in the T cell receptor (TCR)-proximal signalling events underlie the hyporesponsive phenotype. The presence of these anergic antigen-specific T cells may contribute to the failure of the host immune response to promote sterilizing immunity during persistent S. aureus infection and also offers new possibilities for novel immunotherapeutic approaches.

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Language(s): eng - English
 Dates: 2011
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 581471
 Degree: -

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Title: EMBO Molecular Medicine
  Alternative Title : EMBO Mol. Med.
Source Genre: Journal
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Pages: - Volume / Issue: 3 Sequence Number: - Start / End Page: 652 - 666 Identifier: -